Proprotein convertase 2
Proprotein convertase 2 (PC2) also known as prohormone convertase 2 or neuroendocrine convertase 2 (NEC2) is a serine protease and proprotein convertase PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the first step in the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin intermediates. To generate the bioactive form of insulin (and many other peptides), a second step involving the removal of C-terminal basic residues is required; this step is mediated by carboxypeptidases E and/or D. PC2 plays only a minor role in the first step of insulin biosynthesis, but a greater role in the first step of glucagon biosynthesis compared to PC1. PC2 binds to the neuroendocrine protein named 7B2, and if this protein is
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1,2-dimethoxyethaanDynorphinEC 3.4.21.941,2-dimethoxyethaanInsulinList of EC numbers (EC 3)List of MeSH codes (D08)List of human protein-coding genes 3Met-enkephalinPCSK2PCSK2 (gene)PreproinsulinProhormone convertase 21,2-dimethoxyethaanProopiomelanocortinProprotein convertaseProprotein convertase 1SCG5Subtilase
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Proprotein convertase 2
Proprotein convertase 2 (PC2) also known as prohormone convertase 2 or neuroendocrine convertase 2 (NEC2) is a serine protease and proprotein convertase PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the first step in the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin intermediates. To generate the bioactive form of insulin (and many other peptides), a second step involving the removal of C-terminal basic residues is required; this step is mediated by carboxypeptidases E and/or D. PC2 plays only a minor role in the first step of insulin biosynthesis, but a greater role in the first step of glucagon biosynthesis compared to PC1. PC2 binds to the neuroendocrine protein named 7B2, and if this protein is
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Proprotein convertase 2 (PC2) ...... 6, PC7/8, PCSK9, and SKI1/S1P.
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995,793,565
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proprotein convertase 2
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Proprotein convertase 2 (PC2) ...... d 7B2, and if this protein is
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Proprotein convertase 2
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