SMC3
Structural maintenance of chromosomes protein 3 (SMC3) is a protein that in humans is encoded by the SMC3 gene. SMC3 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. In humans, SMC3 is present in all cohesin complexes whereas there are multiple paralogs for the other subunits. SMC3 is a member of the SMC protein family. Members of this family are key regulators of DNA repair, chromosome condensation and chromosome segregation.
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Acute megakaryoblastic leukemiaBamacanCSPG6Chondroitin sulfate proteoglycanChromomereCohesinCornelia de Lange syndromeEstablishment of sister chromatid cohesionGATA1KIF3BKIFAP3List of OMIM disorder codesList of human protein-coding genes 4MXD1MXI1RAD21REC8SGOL1SMC1ASMC1BSMC3 (gene)SMC proteinSTAG1STAG2Smc3Transient myeloproliferative diseaseWAPAL
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SMC3
Structural maintenance of chromosomes protein 3 (SMC3) is a protein that in humans is encoded by the SMC3 gene. SMC3 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. In humans, SMC3 is present in all cohesin complexes whereas there are multiple paralogs for the other subunits. SMC3 is a member of the SMC protein family. Members of this family are key regulators of DNA repair, chromosome condensation and chromosome segregation.
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Structural maintenance of chro ...... on and chromosome segregation.
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Structural maintenance of chro ...... on and chromosome segregation.
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SMC3
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