The second Plague pandemic was a major series of epidemics of plague that started with the Black Death, which reached Europe in 1348 and killed up to a half of the population of Eurasia in the next four years. Although the plague died out in most places, it became endemic and recurred regularly. A series of major epidemics occurred in the late 17th century, and the disease recurred in some places until the late 18th century or the early 19th century. After this, a new strain of the bacterium gave rise to the third plague pandemic which started in Asia around the mid-19th century.