about
Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esteraseThe discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitorsThe N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membraneAdamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.
P921
description
Catalysis of the reaction: an ...... an 11-oxosteroid + NADPH + H+.
@en
moleculaire functie
@nl
name
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
@en
type
label
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
@en
altLabel
11beta-hydroxysteroid:NADP+ 11-oxidoreductase
@en
GO:0070524
@en
corticosteroid 11-beta-dehydrogenase activity
@en
prefLabel
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
@en
P2888
P591
P686
GO:0070524