The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane
about
Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic propertiesAppropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esteraseThe molecular biology, biochemistry, and physiology of human steroidogenesis and its disordersThe role of glucocorticoid action in the pathophysiology of the Metabolic SyndromeOrganotins disrupt the 11beta-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoidsMutations of key hydrophobic surface residues of 11β-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression systemReduced activity of 11 beta-hydroxysteroid dehydrogenase in patients with cholestasisHexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the ratCharting biologically relevant chemical space: a structural classification of natural products (SCONP)In silico structure-function analysis of pathological variation in the HSD11B2 gene sequenceHexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroidsFructose, Glucocorticoids and Adipose Tissue: Implications for the Metabolic Syndrome.Paraventricular hypothalamic nucleus: axonal projections to the brainstem.Cortisone-reductase deficiency associated with heterozygous mutations in 11beta-hydroxysteroid dehydrogenase type 1.High salt intake down-regulates colonic mineralocorticoid receptors, epithelial sodium channels and 11β-hydroxysteroid dehydrogenase type 2Aldosterone-sensitive neurons in the nucleus of the solitary tract: bidirectional connections with the central nucleus of the amygdala.11β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue.Inputs to the ventrolateral bed nucleus of the stria terminalisVagal innervation of the aldosterone-sensitive HSD2 neurons in the NTS.Static retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum.Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1Localisation of 11β-Hydroxysteroid Dehydrogenase Type 2 in Mineralocorticoid Receptor Expressing Magnocellular Neurosecretory Neurones of the Rat Supraoptic and Paraventricular Nuclei.Biomarkers of hypothalamic-pituitary-adrenal axis activity in mice lacking 11β-HSD1 and H6PDHGenetic manipulation of 11beta-hydroxysteroid dehydrogenases in mice.Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.Insulin and dexamethasone dynamically regulate adipocyte 11beta-hydroxysteroid dehydrogenase type 1.Increased glycogen synthase kinase-3β and hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to glucocorticoid-induced mouse visceral adiposityImpaired oxidoreduction by 11β-hydroxysteroid dehydrogenase 1 results in the accumulation of 7-oxolithocholic acid.Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expressionTransgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice.11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.Functional effects of polymorphisms in the human gene encoding 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1): a sequence variant at the translation start of 11 beta-HSD1 alters enzyme levels.Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily.In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3.The immunologically protective P-4 antigen of Leishmania amastigotes. A developmentally regulated single strand-specific nuclease associated with the endoplasmic reticulum.Specific reduction of G6PT may contribute to downregulation of hepatic 11β-HSD1 in diabetic mice.Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.Coffee inhibits the reactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: a glucocorticoid connection in the anti-diabetic action of coffee?Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase.Functional expression, characterization, and purification of the catalytic domain of human 11-beta -hydroxysteroid dehydrogenase type 1.
P2860
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P2860
The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The N-terminal anchor sequence ...... endoplasmic reticulum membrane
@ast
The N-terminal anchor sequence ...... endoplasmic reticulum membrane
@en
The N-terminal anchor sequence ...... endoplasmic reticulum membrane
@nl
type
label
The N-terminal anchor sequence ...... endoplasmic reticulum membrane
@ast
The N-terminal anchor sequence ...... endoplasmic reticulum membrane
@en
The N-terminal anchor sequence ...... endoplasmic reticulum membrane
@nl
prefLabel
The N-terminal anchor sequence ...... endoplasmic reticulum membrane
@ast
The N-terminal anchor sequence ...... endoplasmic reticulum membrane
@en
The N-terminal anchor sequence ...... endoplasmic reticulum membrane
@nl
P2093
P2860
P921
P3181
P356
P1476
The N-terminal anchor sequence ...... endoplasmic reticulum membrane
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.274.40.28762
P407
P577
1999-10-01T00:00:00Z