about
P688
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreasNuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferasep53 family members in myogenic differentiation and rhabdomyosarcoma developmentThe bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcriptionIsolation and characterization of cytoplasmic cyclin D1 mutantsCyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motilityLiver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activityCyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial functionC/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn miceNovel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stressCyclin D1-dependent kinase activity in murine development and mammary tumorigenesisp27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferationLysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradationCyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiationRegulation of the catalytic subunit (p34PSK-J3/cdk4) for the major D-type cyclin in mature B lymphocytesCDK6 kinase activity is required for thymocyte developmentDeath effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in miceSomatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificityGenetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell numberSubnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repressionHsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinaseCDK4 is an essential insulin effector in adipocytesRequirement for CDK4 kinase function in breast cancerGene expression profile analysis of mouse colon embryonic developmentCommon and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse modelDeletion of Mnt leads to disrupted cell cycle control and tumorigenesisConcurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patientsGenetic analysis of Ras signalling pathways in cell proliferation, migration and survival.The EGF receptor is required for efficient liver regeneration
P921
Q24299520-30D843C1-68D2-4FD7-B650-DB297C90C411Q24303548-FC271391-434A-4618-9A91-A4D636B1B733Q24306987-C84D9B53-98B8-4B98-9B78-117C93421882Q24316236-BA01A047-635C-420F-9EE7-A3E1E480A401Q24320363-6C080567-E520-41BB-8401-6F3AC50ECD39Q24337518-E74AD21D-05E2-4787-B968-49D3084EB552Q24337815-B5EC40D7-A1AA-4CE8-B833-F8234BB64A6FQ24554383-CDE670A8-54AE-4D49-BA9D-63E0780FA7D4Q24554514-41A88505-5480-439C-9701-3F16BACA3A39Q24652510-ED23C39B-7AE8-4758-B3CD-E311166639D6Q28215088-BF6BD1D0-3925-4769-8811-6ECA1BEC79F6Q28291864-9FE1C475-0230-4305-A423-DB72B0E17D73Q28505037-1005C798-20AA-4834-A97F-B9BCCA001065Q28505301-41C0D544-970D-4F6E-8A50-F73F876FB845Q28508267-1AD60551-BE58-468E-B506-9676C110273DQ28510551-6B16AD7A-B3A3-4B18-BE19-214A33B36462Q28511696-26A7DE3B-B1EB-4843-8B47-4B9F7F290345Q28512218-C057A2ED-ACE0-4D9A-ACB6-742E3F42F472Q28512780-C3E7FAF2-97C3-4717-8484-6374373B89D7Q28513336-917D026F-1EBB-41A0-98D2-6FF3C3482CC7Q28513987-B62A7783-EC55-437D-A0CF-3BDE2257A18CQ28584893-4B919174-CCA0-495C-9464-D207E0E201F3Q28585407-E12F9A06-49C6-4860-A7BF-CF3F67E84DD4Q28585533-A96EFA95-5394-4E43-B407-098A031A06A9Q28585816-8787E45F-9D0C-4FC0-9276-DFED381887C8Q28585905-B8B8DABA-F123-4406-85F2-42366106204EQ28587663-1CA382DD-EAE5-4F1C-9F3D-A63AABE006F6Q28588011-FA31010C-85EC-4868-AC91-BB530BA2036DQ28589097-1DD4227F-BBB3-42B6-B650-AB5C4873A86AQ28592867-7F73CB45-FE92-418C-A2D9-97908ADF046EQ28595029-5C06DE0D-146B-4FD2-91AE-707DB5964D2FQ36089334-C21A9663-2F5C-4A7B-B90B-2311970A2F2D
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Cyclin-dependent kinase 4
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
Cyclin-dependent kinase 4
@en
type
label
Cyclin-dependent kinase 4
@en
altLabel
CRK3
@en
Cdk4
@en
PSK-J3
@en
cell division protein kinase 4
@en
cyclin-dependent kinase 4
@en
p34<PSK-J3>/cdk4
@en
serine/threonine kinase
@en
prefLabel
Cyclin-dependent kinase 4
@en
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NP_001341934
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ENSMUSP00000006911
ENSMUSP00000112549
ENSMUSP00000116190
ENSMUSP00000117234
ENSMUSP00000122973