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PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitroA systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cellsCDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanismsCyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformationA NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C MutationNew directions for drug-resistant breast cancer: the CDK4/6 inhibitorsA drosophila model for EGFR-Ras and PI3K-dependent human gliomaFragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 InhibitorsD-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells.Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure.Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancersTargeting CDK4 and CDK6: From Discovery to TherapyBrk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4Cyclin D as a therapeutic target in cancerMMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancerCyclin-dependent kinases 4 and 6 control tumor progression and direct glucose oxidation in the pentose cycleFascaplysin as a specific inhibitor for CDK4: insights from molecular modellingDisruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesisHeterogeneity of mammary lesions represent molecular differencesExploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models.Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence.A semi-synthetic ion channel platform for detection of phosphatase and protease activity.ETS-targeted therapy: can it substitute for MEK inhibitors?Modulated expression of genes encoding estrogen metabolizing enzymes by G1-phase cyclin-dependent kinases 6 and 4 in human breast cancer cells.Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasionSUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression.Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37CDK4 inhibition and doxorubicin mediate breast cancer cell apoptosis through Smad3 and survivin.MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2.Cyclin D1 and C/EBPβ LAP1 operate in a common pathway to promote mammary epithelial cell differentiationMiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer.Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells.Oncogenes and tumor suppressor genesPalbociclib (PD 0332991) : targeting the cell cycle machinery in breast cancer.Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesisTumour growth inhibition by an imidazoquinoline is associated with c-Myc down-regulation in urothelial cell carcinoma.Unexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis.Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model.Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis.
P2860
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P2860
description
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Januar 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/01/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/01/01)
@nl
наукова стаття, опублікована в січні 2006
@uk
مقالة علمية (نشرت عام 2006)
@ar
name
Requirement for CDK4 kinase function in breast cancer
@ast
Requirement for CDK4 kinase function in breast cancer
@en
Requirement for CDK4 kinase function in breast cancer
@nl
type
label
Requirement for CDK4 kinase function in breast cancer
@ast
Requirement for CDK4 kinase function in breast cancer
@en
Requirement for CDK4 kinase function in breast cancer
@nl
prefLabel
Requirement for CDK4 kinase function in breast cancer
@ast
Requirement for CDK4 kinase function in breast cancer
@en
Requirement for CDK4 kinase function in breast cancer
@nl
P2093
P3181
P1433
P1476
Requirement for CDK4 kinase function in breast cancer
@en
P2093
Agnieszka Zagozdzon
Ewa Sicinska
Hiroaki Kiyokawa
Humphrey Gardner
Lyndsay N. Harris
Marie Ahnström
Piotr Sicinski
P3181
P356
10.1016/J.CCR.2005.12.012
P577
2006-01-01T00:00:00Z