Identification of direct protein targets of small moleculesFollowing the Path of the Virus: The Exploitation of Host DNA Repair Mechanisms by RetrovirusesAntiviral compounds discovered by virtual screening of small-molecule libraries against dengue virus E proteinDcpS as a therapeutic target for spinal muscular atrophy.Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channelsChemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsMeta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743A stereoelectronic effect in prebiotic nucleotide synthesisReconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donorsFirst-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3GPotent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged proteinSystematic analysis of helical protein interfaces reveals targets for synthetic inhibitorsSceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines.Bright ideas for chemical biologyFunctionalization of β-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid SystemStructure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease VectorSimultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus TherapyFine-tuning multiprotein complexes using small moleculesChemical probes of histone lysine methyltransferasesCurrent chemical biology approaches to interrogate protein methyltransferasesManganese and microbial pathogenesis: sequestration by the Mammalian immune system and utilization by microorganismsDrugging topoisomerases: lessons and challengesMass spectrometry-based detection and assignment of protein posttranslational modificationsExploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?Fifty years of diazeniumdiolate research. From laboratory curiosity to broad-spectrum biomedical advancesGetting in shape: controlling peptide bioactivity and bioavailability using conformational constraintsProtein Termini and Their Modifications Revealed by Positional ProteomicsProtein lysine acylation and cysteine succination by intermediates of energy metabolismIdentification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells.Single-Cell, Time-Resolved Antimicrobial Effects of a Highly Cationic, Random Nylon-3 Copolymer on Live Escherichia coli.Optochemical dissection of T-box gene-dependent medial floor plate developmentRapid, specific, no-wash, far-red fluorogen activation in subcellular compartments by targeted fluorogen activating proteinsImaging complex protein metabolism in live organisms by stimulated Raman scattering microscopy with isotope labeling.One-step enzymatic modification of the cell surface redirects cellular cytotoxicity and parasite tropism.HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel SiteGene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotidePhotoactive analogues of the haloether anesthetics provide high-resolution features from low-affinity interactionsStructural insight into the self-sacrifice mechanism of enediyne resistanceDesign, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPsStructure and properties of a re-engineered homeodomain protein-DNA interface
P1433
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P1433
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Fachzeitschrift
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vědecký časopis
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wetenschappelijk tijdschrift van American Chemical Society
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науковий журнал
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A C S Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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A C S Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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A C S Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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ACS Chemical Biology
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P3181
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ACS Chem. Biol.
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ACS Chemical Biology
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