Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
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Crystallographic studies of chemically modified nucleic acids: a backward glanceThe steric hypothesis for DNA replication and fluorine hydrogen bonding revisited in light of structural dataCrystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzymeStructure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluenePairing Geometry of the Hydrophobic Thymine Analogue 2,4-Difluorotoluene in Duplex DNA as Analyzed by X-ray CrystallographyUnexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNAHydrogen-Bonding Capability of a Templating Difluorotoluene Nucleotide Residue in an RB69 DNA Polymerase Ternary ComplexNovel modifications in RNAChemical modification: the key to clinical application of RNA interference?Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves.Improving gene silencing of siRNAs via tricyclo-DNA modificationMeasurement and theory of hydrogen bonding contribution to isosteric DNA base pairs.7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major grooveSteric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobasesModel systems for understanding DNA base pairing.Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.RNA major groove modifications improve siRNA stability and biological activity.Redesigning the architecture of the base pair: toward biochemical and biological function of new genetic setsHigh-resolution NMR analysis of the conformations of native and base analog substituted retroviral and LTR-retrotransposon PPT primers.Computational approaches to predicting the impact of novel bases on RNA structure and stability.Short interfering RNA guide strand modifiers from computational screening.Chemical modification of siRNA.Chemical modification of siRNA bases to probe and enhance RNA interference.Nucleic-acid based gene therapeutics: delivery challenges and modular design of nonviral gene carriers and expression cassettes to overcome intracellular barriers for sustained targeted expression.Synthesis and properties of small interfering RNA duplexes carrying 5-ethyluridine residues.Effect of north bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification.Modulation of thermal stability can enhance the potency of siRNAChemical modification resolves the asymmetry of siRNA strand degradation in human blood serum.Inhibition of MDR1 expression with altritol-modified siRNAs.Synthesis of N2-alkyl-8-oxo-7,8-dihydro-2'-deoxyguanosine derivatives and effects of these modifications on RNA duplex stability.Efficient syntheses of 5'-deoxy-5'-fluoroguanosine and -inosine.Synthesis and biological applications of fluoro-modified nucleic acids.
P2860
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P2860
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
@ast
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
@en
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
@nl
type
label
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
@ast
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
@en
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
@nl
prefLabel
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
@ast
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
@en
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
@nl
P2093
P356
P1433
P1476
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide
@en
P2093
Akin Akinc
Anne Noronha
Ivanka Toudjarska
Kallanthottathil G Rajeev
Maria Frank-Kamenetsky
Muthiah Manoharan
Ravi Braich
P304
P356
10.1021/CB600063P
P50
P577
2006-04-25T00:00:00Z