A growing toolbox of techniques for studying β-barrel outer membrane protein folding and biogenesisMechanisms of amyloid formation revealed by solution NMRAssessing the causes and consequences of co-polymerization in amyloid formationStructural plasticity and noncovalent substrate binding in the GroEL apical domain. A study using electrospay ionization mass spectrometry and fluorescence binding studiesCrystal structure of monomeric human -2-microglobulin reveals clues to its amyloidogenic propertiesStructural determinants of polymerization reactivity of the P pilus adaptor subunit PapFAmino Acid Insertion Reveals a Necessary Three-Helical Intermediate in the Folding Pathway of the Colicin E7 Immunity Protein Im7Conformational Conversion during Amyloid Formation at Atomic ResolutionPseudospecific docking surfaces on electron transfer proteins as illustrated by pseudoazurin, cytochrome c550 and cytochrome cd1 nitrite reductaseCrystal structure of the mutant D52S hen egg white lysozyme with an oligosaccharide productInstability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesisComparison of the transition state ensembles for folding of Im7 and Im9 determined using all-atom molecular dynamics simulations with phi value restraintsThe origin of the alpha-domain intermediate in the folding of hen lysozymeRole of the single disulphide bond of beta(2)-microglobulin in amyloidosis in vitroA partially folded intermediate species of the beta-sheet protein apo-pseudoazurin is trapped during proline-limited foldingβ2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pHComparison of the aggregation of homologous β2-microglobulin variants reveals protein solubility as a key determinant of amyloid formationLeaf Demography, Sclerophylly and Ecophysiology of Two Banksias With Contrasting Leaf Life SpansA comparison of the folding characteristics of free and ribosome-tethered polypeptide chains using limited proteolysis and mass spectrometryLateral opening in the intact β-barrel assembly machinery captured by cryo-EM.Amphipols outperform dodecylmaltoside micelles in stabilizing membrane protein structure in the gas phase.Dissecting the effects of periplasmic chaperones on the in vitro folding of the outer membrane protein PagPAmphipathic polymers enable the study of functional membrane proteins in the gas phaseThe role of chaperone-subunit usher domain interactions in the mechanism of bacterial pilus biogenesis revealed by ESI-MS.The transition state for folding of an outer membrane protein.The N-terminal helix is a post-assembly clamp in the bacterial outer membrane protein PagP.Rapid folding with and without populated intermediates in the homologous four-helix proteins Im7 and Im9.Beta edge strands in protein structure prediction and aggregation.Trapping the on-pathway folding intermediate of Im7 at equilibrium.Using hydroxyl radical footprinting to explore the free energy landscape of protein folding.Desolvation and development of specific hydrophobic core packing during Im7 folding.Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation.The oligomeric state and arrangement of the active bacterial transloconThe effect of core destabilization on the mechanical resistance of I27.Synthesis, characterization and applications of a perdeuterated amphipol.Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins.Viscoelastic properties of single polysaccharide molecules determined by analysis of thermally driven oscillations of an atomic force microscope cantilever.Unfolding dynamics of proteins under applied force.Using chimeric immunity proteins to explore the energy landscape for alpha-helical protein folding.Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump.
P50
Amyloid fibril cytotoxicity: new insights from novel approachesProbing biomolecular interactions by combining ETD-tandem mass spectrometry with chemical footprinting methodologiesInterrogating the folding and function of membrane proteins by mass spectrometryStructure and dynamics of oligomeric intermediates in amyloid assemblyIn vivo selection of bioprocessable biopharmaceuticalsInvestigating E. coli cell envelope proteins and processes through colicin intoxicationCompatibility rules for glycosaminoglycan-amyloid interactionsHow do ATP-independent chaperones assist OMP folding and assembly? Insights from mass spectrometry and other approachesIntegrative structural biology for mechanisms of protein mis-folding and dysregulation: a Japan-UK partnership between Leeds and OsakaExploring the therapeutic, diagnostic and research applications of anti-amyloid aptamersThe structure and function of the beta-barrel assembly machinery: an Achilles heel of Gram-negative pathogensDeciphering the allosteric mechanism of protein translocation through membranesUnravelling BamA Function Using Fluorescence & Single Molecule Force Experiments
P710
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P184
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P50
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P710
description
British biophysicist
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena E. Radford
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Sheena E. Radford
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Sheena E. Radford
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Sheena E. Radford
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Sheena E. Radford
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Sheena E. Radford
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Sheena E. Radford
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Sheena E. Radford
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Sheena E. Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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Sheena Radford
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P1344
P185
P1015
P214
P244
P269
P6366
P646
P1015
P106
P1153
7005041518