about
The application of the open pharmacological concepts triple store (Open PHACTS) to support drug discovery researchOpen Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationshipsPyridazines. Part 28: 5-alkylidene-6-phenyl-3(2H)-pyridazinones, a new family of platelet aggregation inhibitors.Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns.Divergent solution-phase synthesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists.In silico directed chemical probing of the adenosine receptor family.Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model.New chromene scaffolds for adenosine A(2A) receptors: synthesis, pharmacology and structure-activity relationships.Association of community-acquired pneumonia with antipsychotic drug use in elderly patients: a nested case-control study.Multitarget-directed tricyclic pyridazinones as G protein-coupled receptor ligands and cholinesterase inhibitors.Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening.Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice.Emerging opportunities and concerns for drug discovery at serotonin 5-HT2B receptors.A novel mechanism of neuroprotection: Blood glutamate grabber.Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease.Concise asymmetric syntheses of novel phenanthroquinolizidines.Synthesis by microwave-assisted 1,3-dipolar cycloaddition of 1,2,3-triazole 1'-homo-3'-isoazanucleosides and evaluation of their anticancer activity.Syntheses and cytotoxicity of (R)- and (S)-7-methoxycryptopleurine.The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling.Natural tetraponerines: a general synthesis and antiproliferative activity.The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.Cytocompatibility and P-glycoprotein inhibition of block copolymers: structure-activity relationship.Doxorubicin-loaded micelles of reverse poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) block copolymers as efficient "active" chemotherapeutic agents.Poly(styrene oxide)-poly(ethylene oxide) block copolymers: From "classical" chemotherapeutic nanocarriers to active cell-response inducers.Intracellular delivery of docetaxel using freeze-dried polysaccharide nanocapsules.Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists.Phe369(7.38) at human 5-HT(7) receptors confers interspecies selectivity to antagonists and partial agonists.Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists.Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists.Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists.Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine(2A) receptor homodimers.A new chemical tool (C0036E08) supports the role of adenosine A(2B) receptors in mediating human mast cell activation.Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines.Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells.Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors.Inhibition of P-glycoprotein pumps by PEO-PPO amphiphiles: branched versus linear derivatives.Synthesis, 3D-QSAR, and structural modeling of benzolactam derivatives with binding affinity for the D(2) and D(3) receptors.
P50
Q19845588-2009c8f1-47f5-8251-194e-a879d0b69920Q27826351-FF907644-1AA5-4551-B5DF-F78152D192F4Q28266208-886DEACA-C8D4-4113-A308-F35CC19C51A5Q28298080-760D7582-E3B5-4BAF-8F59-4F81E0377F24Q30695570-1CE8BB91-FB1D-4C4E-B824-8DD25C4BFD4CQ30990011-58865C8C-7AE6-488E-8414-5DBD54F6EEA1Q31202630-138E5757-BF73-454A-84D3-619907B93DFFQ33453741-A104F51D-BDAB-457D-9BA2-EAFA85B2E7FFQ33552006-6C41DA45-E30A-4CED-A1FC-4B7E7B085AB7Q34234232-75E4EED5-E227-43CE-AF67-301D36B8E00EQ34296457-F41BBD54-043F-45CF-81F2-4A467825E725Q34618500-F0946D08-0F81-4A4A-A409-C67D1F834692Q35618019-ADBD12ED-88D9-4A35-BA8E-0956A62552C8Q35994468-22C8C63E-5969-4C8B-8B77-450619DF20EFQ36326799-FEDBD767-F461-4C5E-B07F-84D8509810E7Q37694652-3663B68B-E2DB-42CD-8D62-A6437A37C3C6Q38557491-BCAB39A1-E825-45FC-8DB3-FEEB0F7CA3D1Q38686069-D4007FD5-5030-4117-801B-A234C95A0D77Q38801353-609A219D-C841-40B8-921D-7A71D7969E83Q38869515-46133D37-F34F-4775-8263-AE37E400129AQ38922614-64D29709-F741-4086-8ECC-DB266BB30A32Q38928549-66D6403E-9F75-4A51-9EC6-5F856D1F67A8Q39004385-BC5915E6-38F6-48D8-91A7-C957FE9FF38EQ39058419-638E2696-72F7-4A13-B8D3-ECE5D2BF58D4Q39140114-E8CD4906-659D-4863-A72F-6513BEDC7800Q39199755-AA6FE198-A40E-429C-AA01-85AD3000850FQ39204288-2026372A-CE96-4D21-8F00-BF3DE1F492A2Q39255249-80573082-E385-4CE4-9B25-5F69AA3EE3ABQ39615457-1E6F7BB3-DB86-4BE1-BE70-1FCCEE1DACA0Q39640436-FA17B19A-F207-4CB8-B18C-2FC6F7513CF2Q39742826-5FE45E6B-54D2-489F-A088-BB0D74175D3CQ39775269-5D8F33BF-6309-4F47-9B04-74646ECC021FQ39812376-3A99AB9B-82C4-4549-B2E9-2E60D2BC5F3AQ39874127-D66B9E20-0E79-4144-8407-6A35F05AE35DQ39953016-5EE7AA42-33F9-4AE1-ABAD-3FE4624B8939Q40127036-0826C69A-D5EF-4A30-970D-3A24FF0F92F6Q40298384-A9C06029-F208-4F0A-A806-6D9704DD4276Q41538383-71368531-4926-454C-BCD8-A8D5E35376A7Q42786611-2A2C62DA-4A72-41ED-9E21-8617791EB7C1Q43026301-7B4E69CB-FEF5-4864-9B1D-46D6E415D06F
P50
description
auteur
@nl
hulumtues
@sq
researcher
@en
հետազոտող
@hy
name
Jose Brea
@ast
Jose Brea
@en
Jose Brea
@es
Jose Brea
@nl
type
label
Jose Brea
@ast
Jose Brea
@en
Jose Brea
@es
Jose Brea
@nl
altLabel
Jose Manuel Brea
@en
José Brea
@en
prefLabel
Jose Brea
@ast
Jose Brea
@en
Jose Brea
@es
Jose Brea
@nl
P106
P21
P31
P496
0000-0002-5523-1979
P569
2000-01-01T00:00:00Z