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Direct control of the Forkhead transcription factor AFX by protein kinase BAFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1ZW10 links mitotic checkpoint signaling to the structural kinetochore.Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomicsA phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.Survivin is required for a sustained spindle checkpoint arrest in response to lack of tensionMps1 phosphorylates Borealin to control Aurora B activity and chromosome alignmentCentromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome lossInhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factorsLethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3aThe forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpointCell cycle and death control: long live ForkheadsForkhead transcription factor FOXO3a protects quiescent cells from oxidative stressOn the road to cancer: aneuploidy and the mitotic checkpointForkhead transcription factors: new insights into protein kinase B (c-akt) signaling.Finding the middle ground: how kinetochores power chromosome congression.Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis.Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localizationPreventing aneuploidy: the contribution of mitotic checkpoint proteins.Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint.Joined at the hip: kinetochores, microtubules, and spindle assembly checkpoint signaling.Attachment issues: kinetochore transformations and spindle checkpoint silencing.Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.Difference Makers: Chromosomal Instability versus Aneuploidy in Cancer.Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.Targeting the mitotic checkpoint to kill tumor cells.Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint.Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy.Evolutionary dynamics of the kinetochore network in eukaryotes as revealed by comparative genomics.Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model.Widespread Recurrent Patterns of Rapid Repeat Evolution in the Kinetochore Scaffold KNL1.Unique Phylogenetic Distributions of the Ska and Dam1 Complexes Support Functional Analogy and Suggest Multiple Parallel Displacements of Ska by Dam1.Kinetochore Malfunction in Human Pathologies.Release of Mps1 from kinetochores is crucial for timely anaphase onset.The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
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P50
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Geert J Kops
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Geert Kops
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Geert Kops
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Geert Kops
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Geert J Kops
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Geert Kops
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Geert J Kops
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Geert J Kops
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Geert J Kops
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Geert Kops
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Geert Kops
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Geert Kops
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Geert Kops
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P106
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nWdmhgoAAAAJ
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P31
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0000-0003-3555-5295