Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss
about
Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfismZW10 links mitotic checkpoint signaling to the structural kinetochore.Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interferenceSilencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death.BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosisCell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis.Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delayLethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.A mitotic septin scaffold required for Mammalian chromosome congression and segregationShugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in miceWhen 2+2=5: the origins and fates of aneuploid and tetraploid cellsMicrotubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signalingHURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.Targeting the Mitotic Catastrophe Signaling Pathway in CancerConnecting the speckles: Splicing kinases and their role in tumorigenesis and treatment responseChromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomesKinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components.Chromosomes can congress to the metaphase plate before biorientation.TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment.CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding SitesChromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways.Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo developmentSequential assembly of centromeric proteins in male mouse meiosisKinetochore localization of spindle checkpoint proteins: who controls whom?CLIP-170 facilitates the formation of kinetochore-microtubule attachments.Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.The Ndc80 kinetochore complex forms load-bearing attachments to dynamic microtubule tips via biased diffusion.Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.Chromosome congression in the absence of kinetochore fibres.Mitotic kinesin CENP-E promotes microtubule plus-end elongation.Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski.Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisonsEvolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cellsLoss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.The spindle assembly checkpoint works like a rheostat rather than a toggle switchKinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips.Cenp-meta is required for sustained spindle checkpoint
P2860
372a9f902fddcab73076b0d8662bbdec5e0a30a84bef475d010cc2bdf48ef5bc35afca557ffa624092ed1c2c6bd01b073cad12bc698375873d6f1fa096b33bdb33d8d1836337dc7a09cb22287f99bfcca6560d5ce0c794f861fb03041701b3dc0fc9b381ae158e6a4c565e4bc6d48201abd798fd3ce9eb6dc410810f39231b1020b9bd4ff02b40792617efbec5e90f5302187fb354d43e6613be680b0b307ff0cf943b26ae85c5c4fabe1f79f26e029891788bce
P248
Q24292895-6EC0252B-7142-460C-BFD0-4F4D1B7BF14FQ24294981-DE9845D1-3821-44DC-9B43-1D7B30238E02Q24299902-69DAF31C-75D0-4D4D-BD1F-2FEB43C21B74Q24300469-43D94C94-DC8F-48FF-A08A-60E3117F5902Q24301363-820AE288-6B21-49D1-A97B-4ABE944EA535Q24320279-D5FFB06D-62F7-4BDE-BD16-4739A95A2442Q24324782-474C520B-6207-4A49-B20F-4C802AE43190Q24557528-F9B9A3E7-4B64-411F-B1B9-D61AC9B9BB70Q24561583-622A4365-D9E1-4F6A-8142-07CD4C0F52D6Q24564215-5BB00C1A-AE55-435A-A914-CCE36B23F8DEQ24609823-4BE2BE3C-FF00-46E0-BDDE-C8D9DCF20485Q24652898-5AC55E01-258F-404C-B871-C65F4BBA0AF2Q24658364-7FA4C39B-A3E4-48FB-8688-C500A99E4E19Q24679267-04E8A13A-9F77-4C1F-BDA1-58DDF8E712F6Q24683651-407C12B4-F606-470D-BAE8-15B84E23B0A1Q26778544-80A5389B-A031-4CD2-92CD-B74A920B2AB4Q26824298-F10EE1C4-35CE-46D0-BF31-261A0FD214DBQ27301063-9249971F-B75C-4400-898F-EF2ECDB77F40Q27309180-6DE84231-1E1E-40F9-B074-7FD6B86B6539Q27332199-46002F8E-02AC-468A-BB90-F58AC25690ADQ28115138-EC435937-5C48-4DCC-8C78-40CB64F2A262Q28115322-0B3E71F4-A535-4968-903F-B3D01BBD4F89Q28116932-ED6CAEFD-D3C4-4E15-AAEB-8807FB139BB9Q28478743-D2B14790-8F53-4A10-8266-866CFC26BC70Q28507657-819E09FB-CCD2-4537-88CC-B5B2D987BC09Q30448761-5B35E0AC-25BC-4DD5-B593-451D6E2A7209Q30476694-FC8807ED-0528-499C-8406-A80D16339AFBQ30477599-A6ED56BC-13CD-4A8C-8DA0-3EC3690A5B64Q30490445-96D05F59-E3DA-4EC2-829D-F8E71F3F2F87Q30494019-B298C2EA-D70B-4963-8254-51AC501B550CQ30495251-C673DE4B-FB99-4D09-B9B4-0488078BD41DQ30496766-5D3E3EAA-2955-407C-8607-64776591D9D1Q30502592-C3360F3E-5342-4312-9E35-5701612B124AQ30524222-0F3FB6E5-6A33-4122-B727-AAFFFF51F360Q30531111-ED7482FB-C1F9-4E0C-92A5-E25F15DC906EQ30541696-E1B8F9A9-9F1B-4511-AE4B-1D1F76178041Q30556712-DF5B2BE7-31A2-4786-B57C-17BEF88B554AQ30557537-02A31697-D39B-4FEA-9B3F-B2B8F486AAB1Q30571387-6549A3C6-AE72-421D-A913-95DF1470BA10Q30580716-5A81934F-FB39-446F-90A7-B2DDC1CF433B
P2860
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Centromere-associated protein- ...... due to single chromosome loss
@ast
Centromere-associated protein- ...... due to single chromosome loss
@en
Centromere-associated protein- ...... due to single chromosome loss
@en-gb
Centromere-associated protein- ...... due to single chromosome loss
@nl
type
label
Centromere-associated protein- ...... due to single chromosome loss
@ast
Centromere-associated protein- ...... due to single chromosome loss
@en
Centromere-associated protein- ...... due to single chromosome loss
@en-gb
Centromere-associated protein- ...... due to single chromosome loss
@nl
prefLabel
Centromere-associated protein- ...... due to single chromosome loss
@ast
Centromere-associated protein- ...... due to single chromosome loss
@en
Centromere-associated protein- ...... due to single chromosome loss
@en-gb
Centromere-associated protein- ...... due to single chromosome loss
@nl
P2093
P2860
P921
P3181
P356
P1476
Centromere-associated protein- ...... due to single chromosome loss
@en
P2093
Alain D Silk
Beth A A Weaver
Frances R Putkey
Zahid Q Bonday
P2860
P304
P3181
P356
10.1083/JCB.200303167
P407
P577
2003-08-01T00:00:00Z