Experimental support for the evolution of symmetric protein architecture from a simple peptide motif
about
Why reinvent the wheel? Building new proteins based on ready-made partsProtein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profilesSimplified protein design biased for prebiotic amino acids yields a foldable, halophilic proteinOrigin of a folded repeat protein from an intrinsically disordered ancestorA vocabulary of ancient peptides at the origin of folded proteinsSystematic detection of internal symmetry in proteins using CE-SymmHow to Build a Complex, Functional Propeller Protein, From PartsComputational design of a self-assembling symmetrical β-propeller protein.Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels.Exploring the repeat protein universe through computational protein designCrystal structure of MytiLec, a galactose-binding lectin from the mussel Mytilus galloprovincialis with cytotoxicity against certain cancer cell types.Emergence of symmetric protein architecture from a simple peptide motif: evolutionary models.Engineering chimaeric proteins from fold fragments: 'hopeful monsters' in protein design.Functional Proteins from Short Peptides: Dayhoff's Hypothesis Turns 50.De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.Computational design of a symmetrical β-trefoil lectin with cancer cell binding activity.Prebiotic protein design supports a halophile origin of foldable proteins.An empirical phase diagram approach to investigate conformational stability of "second-generation" functional mutants of acidic fibroblast growth factor-1.Experimental support for the foldability-function tradeoff hypothesis: segregation of the folding nucleus and functional regions in fibroblast growth factor-1Evolution of a protein folding nucleusArtificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases.Creation and structure determination of an artificial protein with three complete sequence repeats.A single aromatic core mutation converts a designed "primitive" protein from halophile to mesophile folding.Circular permutation in proteinsPotential steps in the evolution of a fused trimeric all-β dUTPase involve a catalytically competent fused dimeric intermediate.Investigation of protein quaternary structure via stoichiometry and symmetry ınformation.
P2860
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P2860
Experimental support for the evolution of symmetric protein architecture from a simple peptide motif
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Experimental support for the e ...... re from a simple peptide motif
@ast
Experimental support for the e ...... re from a simple peptide motif
@en
Experimental support for the e ...... re from a simple peptide motif
@en-gb
Experimental support for the e ...... re from a simple peptide motif
@nl
type
label
Experimental support for the e ...... re from a simple peptide motif
@ast
Experimental support for the e ...... re from a simple peptide motif
@en
Experimental support for the e ...... re from a simple peptide motif
@en-gb
Experimental support for the e ...... re from a simple peptide motif
@nl
prefLabel
Experimental support for the e ...... re from a simple peptide motif
@ast
Experimental support for the e ...... re from a simple peptide motif
@en
Experimental support for the e ...... re from a simple peptide motif
@en-gb
Experimental support for the e ...... re from a simple peptide motif
@nl
P2860
P3181
P356
P1476
Experimental support for the e ...... re from a simple peptide motif
@en
P2860
P304
P3181
P356
10.1073/PNAS.1015032108
P407
P577
2011-01-04T00:00:00Z