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Metamorphic proteins mediate evolutionary transitions of structure

Metamorphic proteins mediate evolutionary transitions of structure

http://www.wikidata.org/entity/Q27660427

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Experimental support for the evolution of symmetric protein architecture from a simple peptide motif Why reinvent the wheel? Building new proteins based on ready-made parts Membrane deformation by neolectins with engineered glycolipid binding sites A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission A vocabulary of ancient peptides at the origin of folded proteins Structural gymnastics of multifunctional metamorphic proteins.Evolutionary bridges to new protein folds: design of C-terminal Cro protein chameleon sequences.Effects of point mutations on protein structure are nonexponentially distributed.A polymetamorphic protein.Functional β-propeller lectins by tandem duplications of repetitive units.New structural and functional contexts of the Dx[DN]xDG linear motif: insights into evolution of calcium-binding proteins Computational design of a self-assembling symmetrical β-propeller protein.Subdomain interactions foster the design of two protein pairs with ∼80% sequence identity but different folds.Regulated unfolding of proteins in signaling Origination of the Protein Fold Repertoire from Oily Pluripotent Peptides.Protein conformational switches: from nature to design.Emergence of symmetric protein architecture from a simple peptide motif: evolutionary models.Binding sugars: from natural lectins to synthetic receptors and engineered neolectins.Interpreting functional effects of coding variants: challenges in proteome-scale prediction, annotation and assessment.A NAD(P) reductase like protein is the salicylic acid receptor in the appendix of the Sauromatum guttatum inflorescence.The role of defensive ecological interactions in the evolution of conotoxins.De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.Evolution of a protein folding nucleus Two modes of protein sequence evolution and their compositional dependencies.Potential steps in the evolution of a fused trimeric all-β dUTPase involve a catalytically competent fused dimeric intermediate.Extant fold-switching proteins are widespread.Cooperative amino acid changes shift the response of the σ54-dependent regulator XylR from natural m-xylene towards xenobiotic 2,4-dinitrotoluene

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Metamorphic proteins mediate evolutionary transitions of structure

http://www.wikidata.org/entity/Q27660427

description

2010 nî lūn-bûn

@nan

2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Metamorphic proteins mediate evolutionary transitions of structure

@ast

Metamorphic proteins mediate evolutionary transitions of structure

@en

Metamorphic proteins mediate evolutionary transitions of structure

@nl

type

label

Metamorphic proteins mediate evolutionary transitions of structure

@ast

Metamorphic proteins mediate evolutionary transitions of structure

@en

Metamorphic proteins mediate evolutionary transitions of structure

@nl

prefLabel

Metamorphic proteins mediate evolutionary transitions of structure

@ast

Metamorphic proteins mediate evolutionary transitions of structure

@en

Metamorphic proteins mediate evolutionary transitions of structure

@nl

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PNAS.0912616107

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Metamorphic proteins mediate evolutionary transitions of structure

@en

P2093

Dan S Tawfik

http://www.w3.org/2001/XMLSchema#string

Itamar Yadid

http://www.w3.org/2001/XMLSchema#string

Noam Kirshenbaum

http://www.w3.org/2001/XMLSchema#string

Orly Dym

http://www.w3.org/2001/XMLSchema#string

P2860

3D domain swapping: a mechanism for oligomer assembly

The design and characterization of two proteins with 88% sequence identity but different structure and function

Evolution of a protein fold in vitro

Tachylectin-2: crystal structure of a specific GlcNAc/GalNAc-binding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus

Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion

Continuous molecular evolution of protein-domain structures by single amino acid changes

Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds

Interconversion between two unrelated protein folds in the lymphotactin native state

A -barrel built by the combination of fragments from different folds

NMR structures of two designed proteins with high sequence identity but different fold and function

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scholarly article

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10.1073/PNAS.0912616107

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16

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107

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2010-04-20T00:00:00Z

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