Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps - Wikidata - awgldk - TriplyDB

Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps

Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps

http://www.wikidata.org/entity/Q21131559

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Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms Differential effects of human immunodeficiency virus type 1 Vpu on the stability of BST-2/tetherin HIV Genome-Wide Protein Associations: a Review of 30 Years of Research Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence Vpu Protein: The Viroporin Encoded by HIV-1 How viruses use the endoplasmic reticulum for entry, replication, and assembly The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology Electron tomography of HIV-1 infection in gut-associated lymphoid tissue Arms Race between Enveloped Viruses and the Host ERAD Machinery The p97 ATPase associates with EEA1 to regulate the size of early endosomes Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2 Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes Modulation of HIV-1-host interaction: role of the Vpu accessory protein A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.Redox diversity in ERAD-mediated protein retrotranslocation from the endoplasmic reticulum: a complex puzzle.The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.Quality and quantity control at the endoplasmic reticulum.Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu.The HIV-1 Vpu protein induces apoptosis in Drosophila via activation of JNK signaling HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2.Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins Vpu downmodulates two distinct targets, tetherin and gibbon ape leukemia virus envelope, through shared features in the Vpu cytoplasmic tail.Distribution of HIV-1 infection in different T lymphocyte subsets: antiretroviral therapy-naïve vs. experienced patients.Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation.HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor Cullin E3 ligases and their rewiring by viral factors BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action Identification of Residues in the BST-2 TM Domain Important for Antagonism by HIV-1 Vpu Using a Gain-of-Function Approach.Protein targeting and degradation are coupled for elimination of mislocalized proteins.Viral miniproteins Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.Sequences in gibbon ape leukemia virus envelope that confer sensitivity to HIV-1 accessory protein Vpu.Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.The Emerging Roles of Viroporins in ER Stress Response and Autophagy Induction during Virus Infection HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins.Ubiquitination of BST-2 protein by HIV-1 Vpu protein does not require lysine, serine, or threonine residues within the BST-2 cytoplasmic domain.

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Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps

http://www.wikidata.org/entity/Q21131559

description

2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Multilayered mechanism of CD4 ...... ntion and ERAD targeting steps

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Multilayered mechanism of CD4 ...... ntion and ERAD targeting steps

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Multilayered mechanism of CD4 ...... ntion and ERAD targeting steps

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F Javier Pérez-Victoria

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Javier G Magadán

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Juan S Bonifacino

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Klaus Strebel

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Yihong Ye

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P2860

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum

A membrane protein required for dislocation of misfolded proteins from the ER

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.

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