HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2. - Wikidata - awgldk - TriplyDB

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2.

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2.

http://www.wikidata.org/entity/Q34402446

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Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1 Critical role for bone marrow stromal antigen 2 in acute Chikungunya virus infection.HIV Genome-Wide Protein Associations: a Review of 30 Years of Research The role of BST-2/Tetherin in host protection and disease manifestation NK Cells in HIV Disease Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs Vpu Protein: The Viroporin Encoded by HIV-1 Elimination of HIV-1-infected cells by broadly neutralizing antibodies Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection Counteraction of the multifunctional restriction factor tetherin Differential sensitivities of tetherin isoforms to counteraction by primate lentiviruses.Differential Control of BST2 Restriction and Plasmacytoid Dendritic Cell Antiviral Response by Antagonists Encoded by HIV-1 Group M and O Strains.Tetherin Antagonism by HIV-1 Group M Nef Proteins.A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells.The HIV-1 gp120 CD4-bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individuals Bone marrow stromal antigen 2 (BST-2) DNA is demethylated in breast tumors and breast cancer cells.In COS cells Vpu can both stabilize tetherin expression and counteract its antiviral activity.Conserved molecular signatures in gp120 are associated with the genetic bottleneck during simian immunodeficiency virus (SIV), SIV-human immunodeficiency virus (SHIV), and HIV type 1 (HIV-1) transmission Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors.Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1 Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors.Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity.Antagonism of BST-2/Tetherin Is a Conserved Function of the Env Glycoprotein of Primary HIV-2 Isolates.Enhanced FCGR2A and FCGR3A signaling by HIV viremic controller IgG.Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo.Comprehensive Cross-Clade Characterization of Antibody-Mediated Recognition, Complement-Mediated Lysis, and Cell-Mediated Cytotoxicity of HIV-1 Envelope-Specific Antibodies toward Eradication of the HIV-1 Reservoir.HIV-1 Env- and Vpu-Specific Antibody-Dependent Cellular Cytotoxicity Responses Associated with Elite Control of HIV.HIV-1 Vpu Downmodulates ICAM-1 Expression, Resulting in Decreased Killing of Infected CD4+ T Cells by NK Cells Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation.In vitro functional assessment of natural HIV-1 group M Vpu sequences using a universal priming approach.Novel Acylguanidine-Based Inhibitor of HIV-1.Conserved residues within the HIV-1 Vpu transmembrane-proximal hinge region modulate BST2 binding and antagonism.Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies.Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1.Natural Killer (NK) Cell Education Differentially Influences HIV Antibody-Dependent NK Cell Activation and Antibody-Dependent Cellular Cytotoxicity.Endocytic activity of HIV-1 Vpu: Phosphoserine-dependent interactions with clathrin adaptors.Enhancing Virion Tethering by BST2 Sensitizes Productively and Latently HIV-infected T cells to ADCC Mediated by Broadly Neutralizing Antibodies.

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P2860

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2.

http://www.wikidata.org/entity/Q34402446

description

2014 nî lūn-bûn

@nan

2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

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2014年论文

@wuu

name

HIV Nef and Vpu protect HIV-in ...... wn-modulation of CD4 and BST2.

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HIV Nef and Vpu protect HIV-in ...... wn-modulation of CD4 and BST2.

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HIV Nef and Vpu protect HIV-in ...... wn-modulation of CD4 and BST2.

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HIV Nef and Vpu protect HIV-in ...... wn-modulation of CD4 and BST2.

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HIV Nef and Vpu protect HIV-in ...... wn-modulation of CD4 and BST2.

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HIV Nef and Vpu protect HIV-in ...... wn-modulation of CD4 and BST2.

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HIV Nef and Vpu protect HIV-in ...... wn-modulation of CD4 and BST2.

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HIV Nef and Vpu protect HIV-in ...... wn-modulation of CD4 and BST2.

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HIV Nef and Vpu protect HIV-in ...... wn-modulation of CD4 and BST2.

@en

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Fadi Hajjar

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Jean-Pierre Routy

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Sabelo Lukhele

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Tram N Q Pham

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Éric A Cohen

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P2860

Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps

Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

HIV: cell binding and entry

ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge

Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding

Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein

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