Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans
about
Animal models of polyglutamine diseases and therapeutic approachesUsing C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseasesNeuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock responsen-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's diseaseIntegration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicityrBmαTX14 Increases the Life Span and Promotes the Locomotion of Caenorhabditis ElegansNeuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathwaysEthosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expressionSerotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.Evolutionary conservation of drug action on lipoprotein metabolism-related targets.High throughput screening for neurodegeneration and complex disease phenotypes.Environmental exposure, obesity, and Parkinson's disease: lessons from fat and old worms.The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's diseaseThe transcriptome of Trichuris suis--first molecular insights into a parasite with curative properties for key immune diseases of humans.Basic Caenorhabditis elegans methods: synchronization and observation.Anticancer drug mithramycin interacts with core histones: An additional mode of action of the DNA groove binder.A cellular perspective on conformational disease: the role of genetic background and proteostasis networks.Characterisation of immune cell function in fragment and full-length Huntington's disease mouse modelsMeasuring Food Intake and Nutrient Absorption in Caenorhabditis elegans.Inhibitors of metabolism rescue cell death in Huntington's disease models.Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington's disease.Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.Protein homeostasis in models of aging and age-related conformational disease.Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases?Autophagy - An Emerging Anti-Aging Mechanism.Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans.What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.Six psychotropics for pre-symptomatic & early Alzheimer's (MCI), Parkinson's, and Huntington's disease modification.Neurodegenerative disorders: insights from the nematode Caenorhabditis elegansMolecular mechanisms and potential therapeutical targets in Huntington's disease.Chemistry and the worm: Caenorhabditis elegans as a platform for integrating chemical and biological research.Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration.Animal models of neurodegenerative diseases.Huntington's Disease: Pathogenic Mechanisms and Therapeutic Targets.Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts.Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing.Versatile size-dependent sorting of C. elegans nematodes and embryos using a tunable microfluidic filter structure.
P2860
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P2860
Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans
description
2007 nî lūn-bûn
@nan
2007 թուականին հրատարակուած գիտական յօդուած
@hyw
2007 թվականին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Identification of potential th ...... e using Caenorhabditis elegans
@ast
Identification of potential th ...... e using Caenorhabditis elegans
@en
Identification of potential th ...... e using Caenorhabditis elegans
@en-gb
Identification of potential th ...... e using Caenorhabditis elegans
@nl
type
label
Identification of potential th ...... e using Caenorhabditis elegans
@ast
Identification of potential th ...... e using Caenorhabditis elegans
@en
Identification of potential th ...... e using Caenorhabditis elegans
@en-gb
Identification of potential th ...... e using Caenorhabditis elegans
@nl
prefLabel
Identification of potential th ...... e using Caenorhabditis elegans
@ast
Identification of potential th ...... e using Caenorhabditis elegans
@en
Identification of potential th ...... e using Caenorhabditis elegans
@en-gb
Identification of potential th ...... e using Caenorhabditis elegans
@nl
P2093
P2860
P3181
P1433
P1476
Identification of potential th ...... e using Caenorhabditis elegans
@en
P2093
Anne C Hart
Brent R Stockwell
Cindy Voisine
Emily A Bates
Hemant Varma
Nicola Walker
P2860
P3181
P356
10.1371/JOURNAL.PONE.0000504
P407
P577
2007-01-01T00:00:00Z