Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. - Wikidata - awgldk - TriplyDB

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation.

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation.

http://www.wikidata.org/entity/Q33694463

about

Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1 SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series Spatial protein quality control and the evolution of lineage-specific ageing Aging as an event of proteostasis collapse Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways Connecting the dots in Huntington's disease with protein interaction networks Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity UBA1: At the Crossroads of Ubiquitin Homeostasis and Neurodegeneration Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes Integrated control of protein degradation in C. elegans muscle Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's Disease Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway Global functional analyses of cellular responses to pore-forming toxins Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response Identification of a tissue-selective heat shock response regulatory network Widespread protein aggregation as an inherent part of aging in C. elegans Novel polyglutamine model uncouples proteotoxicity from aging A genetic screening strategy identifies novel regulators of the proteostasis network Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.The struggle by Caenorhabditis elegans to maintain proteostasis during aging and disease A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging Characterization of the proteostasis roles of glycerol accumulation, protein degradation and protein synthesis during osmotic stress in C. elegans A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model.HSF1 protects neurons through a novel trimerization- and HSP-independent mechanism Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging Stress and aging induce distinct polyQ protein aggregation states Dynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo.Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects

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P2860

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation.

http://www.wikidata.org/entity/Q33694463

description

2004 nî lūn-bûn

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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2004 թվականի ապրիլին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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Genome-wide RNA interference s ...... of polyglutamine aggregation.

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Genome-wide RNA interference s ...... of polyglutamine aggregation.

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type

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Genome-wide RNA interference s ...... of polyglutamine aggregation.

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Genome-wide RNA interference s ...... of polyglutamine aggregation.

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Genome-wide RNA interference s ...... of polyglutamine aggregation.

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Genome-wide RNA interference s ...... of polyglutamine aggregation.

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P2093

Alejandro Chavez

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Ellen A A Nollen

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Richard I Morimoto

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Ronald H A Plasterk

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Soojin Kim

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Susana M Garcia

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P2860

The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans

Regulation of aging and age-related disease by DAF-16 and heat-shock factor

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

Quality control in the endoplasmic reticulum

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.

Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes.

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6403-6408

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10.1073/PNAS.0307697101

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17

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101

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Gijs van Haaften

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2004-04-14T00:00:00Z

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8618105

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15084750

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404057

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