LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines
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The spatial distribution of LGR5+ cells correlates with gastric cancer progressionLGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressorOverexpression of Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 (LGR5) Represents a Typical Wnt/β-Catenin Pathway-Activated Hepatocellular CarcinomaG Protein-Coupled Receptor Signaling in Stem Cells and CancerWhat Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer TissueLgr5 over-expression is positively related to the tumor progression and HER2 expression in stage pTNM IV colorectal cancerLocal control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgutA novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patientsPost-translational glycoprotein modifications regulate colon cancer stem cells and colon adenoma progression in Apc(min/+) mice through altered Wnt receptor signaling.LGR5 promotes the proliferation and tumor formation of cervical cancer cells through the Wnt/β-catenin signaling pathway.Colorectal cancer stem cells and their implications for novel anticancer therapy.Profiles of cancer stem cell subpopulations in cholangiocarcinomas.LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human AdrenalMetastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling.The first European interdisciplinary ewing sarcoma research summitProgastrin overexpression imparts tumorigenic/metastatic potential to embryonic epithelial cells: phenotypic differences between transformed and nontransformed stem cells.Single nucleotide polymorphisms of the adult intestinal stem cell marker Lgr5 in primary and metastatic colorectal cancer.LGR5 is associated with tumor aggressiveness in papillary thyroid cancer.LGR5 is a promising biomarker for patients with stage I and II gastric cancerColorectal cancer biomarkers and the potential role of cancer stem cells.Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiationLessons learned about human stem cell responses to ionizing radiation exposures: a long road still ahead of us.Knockdown of LGR5 suppresses the proliferation of glioma cells in vitro and in vivo.Cell surface galectin-3 defines a subset of chemoresistant gastrointestinal tumor-initiating cancer cells with heightened stem cell characteristics.Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies.Effect of tumor suppressor gene cyclin-dependent kinase inhibitor 2A wild-type and A148T mutant on the cell cycle of human ovarian cancer cells.CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus.LGR5 positivity defines stem-like cells in colorectal cancer.Lgr5 and Lgr6 as markers to study adult stem cell roles in self-renewal and cancer.Gut stem cells in tissue renewal and disease: methods, markers, and myths.Intestinal stem cells - types and markers.Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter.Cancer Stem Cells: A Moving TargetStructure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells.Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells.Biomarkers and signaling pathways of colorectal cancer stem cells.The Effect of Analogues of 1α,25-Dihydroxyvitamin D₂ on the Regrowth and Gene Expression of Human Colon Cancer Cells Refractory to 5-Fluorouracil.LGR5 promotes the proliferation of colorectal cancer cells via the Wnt/β-catenin signaling pathway.Correlation of Musashi-1, Lgr5, and pEGFR expressions in human small intestinal adenocarcinomas.RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer.
P2860
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P2860
LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines
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2011 nî lūn-bûn
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2011 թուականին հրատարակուած գիտական յօդուած
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2011 թվականին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@ast
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@en
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@en-gb
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@nl
type
label
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@ast
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@en
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@en-gb
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@nl
altLabel
LGR5 Is a Negative Regulator o ...... n Colorectal Cancer Cell Lines
@en
prefLabel
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@ast
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@en
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@en-gb
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@nl
P2093
P2860
P3181
P1433
P1476
LGR5 is a negative regulator o ...... n colorectal cancer cell lines
@en
P2093
Annalisa Odorizzi
Antony W Burgess
Francesca Walker
Hui-Hua Zhang
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0022733
P407
P577
2011-01-01T00:00:00Z