LGR5 positivity defines stem-like cells in colorectal cancer. - Wikidata - awgldk - TriplyDB

LGR5 positivity defines stem-like cells in colorectal cancer.

LGR5 positivity defines stem-like cells in colorectal cancer.

http://www.wikidata.org/entity/Q37687330

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Cancer stem cells--important players in tumor therapy resistance Use of Cancer Stem Cells to Investigate the Pathogenesis of Colitis-associated Cancer What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study.Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis.Emerging understanding of multiscale tumor heterogeneity The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer.Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice.Epigenetic regulation of CD271, a potential cancer stem cell marker associated with chemoresistance and metastatic capacity ERBB3 Positively Correlates with Intestinal Stem Cell Markers but Marks a Distinct Non Proliferative Cell Population in Colorectal Cancer.Lgr5 Methylation in Cancer Stem Cell Differentiation and Prognosis-Prediction in Colorectal Cancer Transcriptome profiling of LGR5 positive colorectal cancer cells.ERBB4 is over-expressed in human colon cancer and enhances cellular transformation Heterogeneity of Cancer Stem Cells: Rationale for Targeting the Stem Cell Niche.Salinomycin inhibits metastatic colorectal cancer growth and interferes with Wnt/β-catenin signaling in CD133(+) human colorectal cancer cells.Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress.LGR5 rs17109924 is a predictive genetic biomarker for time to recurrence in patients with colon cancer treated with 5-fluorouracil-based adjuvant chemotherapy.Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer.BMP signalling in human fetal ovary somatic cells is modulated in a gene-specific fashion by GREM1 and GREM2 Rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk.Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies.Co-expression of Lgr5 and CXCR4 characterizes cancer stem-like cells of colorectal cancer.Loss of ZG16 is regulated by miR-196a and contributes to stemness and progression of colorectal cancer.LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma.Cancer stem cells in human digestive tract malignancies.FOXD3 Regulates CSC Marker, DCLK1-S, and Invasive Potential: Prognostic Implications in Colon Cancer.The third dimension: new developments in cell culture models for colorectal research.MiR-491 attenuates cancer stem cells-like properties of hepatocellular carcinoma by inhibition of GIT-1/NF-κB-mediated EMT.LGR5 promotes the proliferation of colorectal cancer cells via the Wnt/β-catenin signaling pathway.Correlation of Musashi-1, Lgr5, and pEGFR expressions in human small intestinal adenocarcinomas.PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells.An Overview of Lipid Droplets in Cancer and Cancer Stem Cells.Obesity promotes colonic stem cell expansion during cancer initiation.LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer.Targeting colorectal cancer (stem-like) cells using LGR5 directed antibody drug conjugates.Cancer stem cell surface markers on normal stem cells.Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells.

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P2860

LGR5 positivity defines stem-like cells in colorectal cancer.

http://www.wikidata.org/entity/Q37687330

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2013 nî lūn-bûn

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name

LGR5 positivity defines stem-like cells in colorectal cancer.

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LGR5 positivity defines stem-like cells in colorectal cancer.

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type

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LGR5 positivity defines stem-like cells in colorectal cancer.

@en

LGR5 positivity defines stem-like cells in colorectal cancer.

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prefLabel

LGR5 positivity defines stem-like cells in colorectal cancer.

@en

LGR5 positivity defines stem-like cells in colorectal cancer.

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LGR5 positivity defines stem-like cells in colorectal cancer.

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Hans Clevers

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Jordi Camps

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Katherine McKinnon

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Nicole McNeil

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Timo Gaiser

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Yue Hu

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P2860

LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice

Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis

The consequences of chromosomal aneuploidy on the transcriptome of cancer cells

A genetic model for colorectal tumorigenesis

Stem cells, cancer, and cancer stem cells

Identification of stem cells in small intestine and colon by marker gene Lgr5

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

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10.1093/CARCIN/BGT377

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colorectal cancer

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