A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway
about
The CK1 Family: Contribution to Cellular Stress Response and Its Role in CarcinogenesisThe E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factorCircadian clock control of the cellular response to DNA damageGenomic screening with RNAi: results and challengesA genome-wide RNAi screen for modifiers of the circadian clock in human cellsPharmacological modulators of the circadian clock as potential therapeutic drugs: focus on genotoxic/anticancer therapyProtecting the melatonin rhythm through circadian healthy light exposureThe circadian clock in cancer development and therapyCircadian clock protein BMAL1 regulates cellular senescence in vivoFunction-based gene identification using enzymatically generated normalized shRNA library and massive parallel sequencing.Healthy clocks, healthy body, healthy mindPooled RNAi Screens - Technical and Biological Aspects.Circadian rhythm and its role in malignancyCircadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action.Circadian gene variants in cancer.Optimized PCR conditions and increased shRNA fold representation improve reproducibility of pooled shRNA screens.A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells.Aberrant expression of clock gene period1 and its correlations with the growth, proliferation and metastasis of buccal squamous cell carcinoma.Association of the circadian factor Period 2 to p53 influences p53's function in DNA-damage signalingDisrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes.Vigilance and validation: Keys to success in RNAi screening.Age-related BMAL1 change affects mouse bone marrow stromal cell proliferation and osteo-differentiation potential.The circadian control of skin and cutaneous photodamage.The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma.Deregulated expression of cryptochrome genes in human colorectal cancer.RNA-sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents.Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC).Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.Image-predicated sorting of adherent cells using photopatterned hydrogelsCircadian rhythms and cancer.Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock.The circadian clock and the hypoxic response pathway in kidney cancer.Cross-talk between the circadian clock and the cell cycle in cancer.A Perspective on the Future of High-Throughput RNAi Screening: Will CRISPR Cut Out the Competition or Can RNAi Help Guide the Way?The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination.Construction of a plasmid for overexpression of human circadian gene period2 and its biological activity in osteosarcoma cells.Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen.A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3Synthetic lethal hubs associated with vincristine resistant neuroblastoma.A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment.
P2860
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P2860
A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
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2009 թվականին հրատարակված գիտական հոդված
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2009年の論文
@ja
2009年論文
@yue
2009年論文
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2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
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name
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@ast
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@en
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@en-gb
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@nl
type
label
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@ast
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@en
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@en-gb
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@nl
altLabel
A Large Scale shRNA Barcode Sc ...... e p53 Tumor Suppressor Pathway
@en
prefLabel
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@ast
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@en
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@en-gb
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@nl
P2093
P2860
P1433
P1476
A large scale shRNA barcode sc ...... e p53 tumor suppressor pathway
@en
P2093
Armida W M Fabius
Jasper Mullenders
Mandy Madiredjo
Roderick L Beijersbergen
P2860
P356
10.1371/JOURNAL.PONE.0004798
P407
P577
2009-01-01T00:00:00Z