APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis
about
DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositidesKinase activation through dimerization by human SH2-BThe adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-KitSH2-B is required for both male and female reproductionAPS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytesFunctional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, LnkA PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptorRegulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, LnkRegulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor proteinIncreased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domainsSlap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes.Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.Negative regulation of receptor tyrosine kinase signals.Hematopoietic cell-specific adapter proteins, SLP-76 and BLNK, effectively activate NF-AT as well as NF-kappaB by Syk and Tec PTKs in non-lymphoid cell lines.High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions.Antagonizing c-Cbl enhances EGFR-dependent corneal epithelial homeostasisSH2B1 regulation of energy balance, body weight, and glucose metabolism.The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons.SH2-B family members differentially regulate JAK family tyrosine kinases.Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.RETRACTED: Silencing of B cell receptor signals in human naive B cells.Beyond the RING: CBL proteins as multivalent adapters.Lnk adaptor: novel negative regulator of B cell lymphopoiesis.Modulation of gurken translation by insulin and TOR signaling in Drosophila.c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice.SH2B3 (LNK) mutations from myeloproliferative neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F.Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617FNucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genesControl of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins.The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling.Tyrosine residues direct the ubiquitination and degradation of the NY-1 hantavirus G1 cytoplasmic tailDirect binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase.Adapter protein with a pleckstrin homology (PH) and an Src homology 2 (SH2) domain (APS) and SH2-B enhance insulin-receptor autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3-kinase-dependent signalling.Platelet-derived growth factors and their receptors in normal and malignant hematopoiesisThe APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor.
P2860
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P2860
APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@ast
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@en
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@en-gb
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@nl
type
label
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@ast
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@en
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@en-gb
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@nl
prefLabel
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@ast
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@en
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@en-gb
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@nl
P2093
P356
P1433
P1476
APS, an adaptor protein contai ...... ibits PDGF-induced mitogenesis
@en
P2093
A Yoshimura
H Sakamoto
H Yasukawa
M Yokouchi
P2888
P304
P356
10.1038/SJ.ONC.1202326
P407
P577
1999-01-21T00:00:00Z
P5875
P6179
1051400241