Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.
about
SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signalingInteraction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowthSH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiationKinase activation through dimerization by human SH2-BSH2-B is required for both male and female reproductionRegulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsSH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branchesRegulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor proteinA bipolar clamp mechanism for activation of Jak-family protein tyrosine kinasesSH2B1 regulation of energy balance, body weight, and glucose metabolism.Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.The adaptor protein SH2B1β reduces hydrogen peroxide-induced cell death in PC12 cells and hippocampal neurons.Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signalingPhosphorylation controls a dual-function polybasic nuclear localization sequence in the adapter protein SH2B1β to regulate its cellular function and distributionNew function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowthAdapter protein SH2B1beta binds filamin A to regulate prolactin-dependent cytoskeletal reorganization and cell motility.Identification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number.Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10.Human SH2B1 mutations are associated with maladaptive behaviors and obesity.Phosphorylation of the adaptor protein SH2B1β regulates its ability to enhance growth hormone-dependent macrophage motilityAdapter protein SH2B1beta cross-links actin filaments and regulates actin cytoskeletonNucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genesDisruption of the SH2-B gene causes age-dependent insulin resistance and glucose intoleranceSH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin.SH2B1 in β-cells regulates glucose metabolism by promoting β-cell survival and islet expansion.SH2B1 in β-cells promotes insulin expression and glucose metabolism in mice.The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active stateThe Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling.SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells.Adapter protein SH2-B beta undergoes nucleocytoplasmic shuttling: implications for nerve growth factor induction of neuronal differentiation.Adapter protein with a pleckstrin homology (PH) and an Src homology 2 (SH2) domain (APS) and SH2-B enhance insulin-receptor autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3-kinase-dependent signalling.Phosphorylation of the Unique C-terminal Tail of the Alpha Isoform of the Scaffold Protein SH2B1 Controls the Ability of SH2B1alpha to Enhance Nerve Growth Factor Function.SH2B1 promotes NSCLC cell proliferation through PI3K/Akt/mTOR signaling cascade
P2860
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P2860
Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.
@ast
Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.
@en
type
label
Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.
@ast
Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.
@en
prefLabel
Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.
@ast
Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.
@en
P2093
P2860
P356
P1476
Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.
@en
P2093
P2860
P304
40940-40948
P356
10.1074/JBC.M104191200
P407
P577
2001-08-13T00:00:00Z