A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients
about
Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylasesExpression regulation of major histocompatibility complex class I and class II encoding genesInterferon-gamma induces major histocompatibility class II transactivator (CIITA), which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cellsThe zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcriptionRole for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoterClass II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK.New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis studyThe bare lymphocyte syndrome: molecular clues to the transcriptional regulation of major histocompatibility complex class II genes.Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndromeCIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivationAssociations and interactions between bare lymphocyte syndrome factorsClass II transactivator: mastering the art of major histocompatibility complex expressionMutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complexA functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-YAn ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertensionThe ankyrin repeat as molecular architecture for protein recognitionMurine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expressionNLRC5, at the Heart of Antigen PresentationDiacylglycerol kinase zeta in hypothalamus interacts with long form leptin receptor. Relation to dietary fat and body weight regulationHuman regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX membersExpression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAPThe ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1Identification of CIITA regulated genetic module dedicated for antigen presentation.The Epstein-Barr virus promoter initiating B-cell transformation is activated by RFX proteins and the B-cell-specific activator protein BSAP/Pax5Impaired regulation of HLA-DR expression in human immunodeficiency virus-infected monocytes.Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter.Two distinct domains within CIITA mediate self-association: involvement of the GTP-binding and leucine-rich repeat domainsNon-classical transcriptional regulation of HLA-G: an update.Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activationRestricted expression and photic induction of a novel mouse regulatory factor X4 transcript in the suprachiasmatic nucleus.Cellular and gene therapy for major histocompatibility complex class II deficiency.Regulation of major histocompatibility complex class II gene expression, genetic variation and disease.Combined immunodeficiency evolving into predominant CD4+ lymphopenia caused by somatic chimerism in JAK3Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association.Nonproteolytic roles of 19S ATPases in transcription of CIITApIV genes.CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complexClinical course of patients with major histocompatibility complex class II deficiency.Expression of RAB4B, a protein governing endocytic recycling, is co-regulated with MHC class II genes.De novo-developed antibodies to donor MHC antigens lead to dysregulation of microRNAs and induction of MHC class IIInhibition of MHC II gene transcription by nitric oxide and antioxidants.
P2860
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P2860
A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients
description
1998 nî lūn-bûn
@nan
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
A gene encoding a novel RFX-as ...... C class II deficiency patients
@ast
A gene encoding a novel RFX-as ...... C class II deficiency patients
@en
A gene encoding a novel RFX-as ...... C class II deficiency patients
@en-gb
A gene encoding a novel RFX-as ...... C class II deficiency patients
@nl
type
label
A gene encoding a novel RFX-as ...... C class II deficiency patients
@ast
A gene encoding a novel RFX-as ...... C class II deficiency patients
@en
A gene encoding a novel RFX-as ...... C class II deficiency patients
@en-gb
A gene encoding a novel RFX-as ...... C class II deficiency patients
@nl
prefLabel
A gene encoding a novel RFX-as ...... C class II deficiency patients
@ast
A gene encoding a novel RFX-as ...... C class II deficiency patients
@en
A gene encoding a novel RFX-as ...... C class II deficiency patients
@en-gb
A gene encoding a novel RFX-as ...... C class II deficiency patients
@nl
P2093
P921
P356
P1433
P1476
A gene encoding a novel RFX-as ...... C class II deficiency patients
@en
P2093
D F Hochstrasser
J C Sanchez
K Masternak
M Zufferey
R Aebersold
P2888
P356
10.1038/3081
P407
P577
1998-11-01T00:00:00Z
P6179
1033573601