Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias
about
Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk geneMyeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia proteinThe ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.Regulation of the human LAT gene by the Elf-1 transcription factorA stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesisThe oncogenic role of the ETS transcription factors MEF and ERGRoles and regulations of the ETS transcription factor ELF4/MEFAML1 interconnected pathways of leukemogenesisInteractions between the leukaemia-associated ETO homologues of nuclear repressor proteinsWhole-genome analysis informs breast cancer response to aromatase inhibitionThe rate of spontaneous mutations in human myeloid cellsMethylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.A genetic basis of susceptibility to acute pyelonephritis.AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.Regulation of Ets function by protein - protein interactions.Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.Common themes in the pathogenesis of acute myeloid leukemia.Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitorsSpecific protein redirection as a transcriptional therapy approach for t(8;21) leukemiaNuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation.Cell type dependent regulation of multidrug resistance-1 gene expression by AML1-ETO.Predicting the effect of transcription therapy in hematologic malignancies.AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiencyFARE-CAFE: a database of functional and regulatory elements of cancer-associated fusion events.ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemiaCell cycle and developmental control of hematopoiesis by Runx1.Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation.Leukemia and hematopoietic stem cells: balancing proliferation and quiescence.Is it important to decipher the heterogeneity of "normal karyotype AML"?The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineageELF4 is critical for induction of type I interferon and the host antiviral response.New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivoGenomic and biochemical insights into the specificity of ETS transcription factors.Cyclin A-dependent phosphorylation of the ETS-related protein, MEF, restricts its activity to the G1 phase of the cell cycle.Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells.Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription.Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2.
P2860
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P2860
Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Functional and physical intera ...... of t(8;21)-positive leukemias
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Functional and physical intera ...... of t(8;21)-positive leukemias
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Functional and physical intera ...... of t(8;21)-positive leukemias
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Functional and physical intera ...... of t(8;21)-positive leukemias
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type
label
Functional and physical intera ...... of t(8;21)-positive leukemias
@ast
Functional and physical intera ...... of t(8;21)-positive leukemias
@en
Functional and physical intera ...... of t(8;21)-positive leukemias
@en-gb
Functional and physical intera ...... of t(8;21)-positive leukemias
@nl
prefLabel
Functional and physical intera ...... of t(8;21)-positive leukemias
@ast
Functional and physical intera ...... of t(8;21)-positive leukemias
@en
Functional and physical intera ...... of t(8;21)-positive leukemias
@en-gb
Functional and physical intera ...... of t(8;21)-positive leukemias
@nl
P2093
P2860
P921
P356
P1476
Functional and physical intera ...... of t(8;21)-positive leukemias
@en
P2093
P2860
P304
P356
10.1128/MCB.19.5.3635
P407
P577
1999-05-01T00:00:00Z