Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions
about
HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxisNegative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivitySubunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machineryStructure--function relationships in HIV-1 Nef.Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functionsNef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathwaysThe Nef protein of HIV-1 associates with rafts and primes T cells for activationRho GTPases in hematopoiesis and hemopathiesHIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activationHow HIV takes advantage of the cytoskeleton in entry and replicationVav family exchange factors: an integrated regulatory and functional viewConformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assemblyHuman immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell deathArhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosisTyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcriptionLentivirus Nef specifically activates Pak2.A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins.The HIV-1 Nef protein as a target for antiretroviral therapy.Structural determinants for the biological activity of Vav proteins.The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Role of the proline-rich motif of bovine leukemia virus transmembrane protein gp30 in viral load and pathogenicity in sheepSimian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques.Conservation of the central proline-rich (PxxP) motifs of human immunodeficiency virus type 1 Nef protein during the disease progression in two hemophiliac patients.HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo.Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 NefPatterns of HIV-1 protein interaction identify perturbed host-cellular subsystemsChimeric human immunodeficiency virus type 1 virions that contain the simian immunodeficiency virus nef gene are cyclosporin A resistant.Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivityIdentification of protein kinases dysregulated in CD4(+) T cells in pathogenic versus apathogenic simian immunodeficiency virus infection.Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression.MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1.Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.Vav proteins, adaptors and cell signaling.Activation of Vav by the gammaherpesvirus M2 protein contributes to the establishment of viral latency in B lymphocytesHIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity.Nef inhibits glucose uptake in adipocytes and contributes to insulin resistance in human immunodeficiency virus type I infection.Nef alleles from human immunodeficiency virus type 1-infected long-term-nonprogressor hemophiliacs with or without late disease progression are defective in enhancing virus replication and CD4 down-regulation.Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions.HIV-1 Nef is transferred from expressing T cells to hepatocytic cells through conduits and enhances HCV replication.
P2860
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P2860
Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Activation of Vav by Nef induc ...... downstream effector functions
@ast
Activation of Vav by Nef induc ...... downstream effector functions
@en
Activation of Vav by Nef induc ...... downstream effector functions
@en-gb
Activation of Vav by Nef induc ...... downstream effector functions
@nl
type
label
Activation of Vav by Nef induc ...... downstream effector functions
@ast
Activation of Vav by Nef induc ...... downstream effector functions
@en
Activation of Vav by Nef induc ...... downstream effector functions
@en-gb
Activation of Vav by Nef induc ...... downstream effector functions
@nl
prefLabel
Activation of Vav by Nef induc ...... downstream effector functions
@ast
Activation of Vav by Nef induc ...... downstream effector functions
@en
Activation of Vav by Nef induc ...... downstream effector functions
@en-gb
Activation of Vav by Nef induc ...... downstream effector functions
@nl
P2093
P1433
P1476
Activation of Vav by Nef induc ...... downstream effector functions
@en
P2093
P304
P356
10.1016/S1097-2765(01)80005-8
P407
P577
1999-06-01T00:00:00Z