Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef. - Wikidata - awgldk - TriplyDB

Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

http://www.wikidata.org/entity/Q34302168

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Small molecule inhibitors of the HIV-1 virulence factor, Nef Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody Identification of a candidate therapeutic autophagy-inducing peptide A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis.Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.Phylogenetic analysis of population-based and deep sequencing data to identify coevolving sites in the nef gene of HIV-1.Development and validation of a high-content bimolecular fluorescence complementation assay for small-molecule inhibitors of HIV-1 Nef dimerization.Self-association of the Lentivirus protein, Nef Trans-cellular introduction of HIV-1 protein Nef induces pathogenic response in Caenorhabditis elegans.Structural constraints on human immunodeficiency virus type 1 Nef function.Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.Intra- and intersubtype alternative Pak2-activating structural motifs of human immunodeficiency virus type 1 Nef Proteomic profiling of SupT1 cells reveal modulation of host proteins by HIV-1 Nef variants Maintenance of Nef-mediated modulation of major histocompatibility complex class I and CD4 after sexual transmission of human immunodeficiency virus type 1 Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists.CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes.Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function.Caveolin-1 reduces HIV-1 infectivity by restoration of HIV Nef mediated impairment of cholesterol efflux by apoA-I.A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2 Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain.HIV-1 Nef: at the crossroads A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.Retroviral proteomics and interactomes: intricate balances of cell survival and viral replication.Mechanisms of HIV-1 Nef function and intracellular signaling.Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms.The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection.Proteomics in the investigation of HIV-1 interactions with host proteins.Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2.HLA-DQB1*06 and breadth of Nef core region-specific T-cell response are associated with slow disease progression in antiretroviral therapy-naive Chinese HIV-1 subtype B patients.The human immunodeficiency virus type 1 Nef and Vpu proteins downregulate the natural killer cell-activating ligand PVR.Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef HIV-1 Nef: hacker of the host cell.Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue.

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Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

http://www.wikidata.org/entity/Q34302168

description

2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

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Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

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Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

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type

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Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

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Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

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Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

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prefLabel

Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

@ast

Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

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Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

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JVI.80.3.1311-1320.2006

P1433

Journal of Virology

P1476

Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

@en

P2093

Eduardo O'Neill

http://www.w3.org/2001/XMLSchema#string

J Victor Garcia

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John F Krisko

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John L Foster

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Lillian S Kuo

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P2860

HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

An African HIV-1 sequence from 1959 and implications for the origin of the epidemic

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

Structure--function relationships in HIV-1 Nef.

Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

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1311-1320

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scholarly article

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10.1128/JVI.80.3.1311-1320.2006

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3

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80

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Diana R. Tomchick

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2006-02-01T00:00:00Z

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7357364

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16415008

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1346962

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