Identification of a novel gene encoding a p53-associated protein
about
Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequenceTopors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor proteinProtein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptidePlk1-mediated phosphorylation of Topors regulates p53 stabilityTOPORS, implicated in retinal degeneration, is a cilia-centrosomal proteinMutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophyTopors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivoDeath effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanismInhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, ToporsRegulatory functional territory of PLK-1 and their substrates beyond mitosis.Nuclear structure and chromosome segregation in Drosophila male meiosis depend on the ubiquitin ligase dTopors.TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.Stimulation of in vitro sumoylation by Slx5-Slx8: evidence for a functional interaction with the SUMO pathwayPlk1 phosphorylation of Topors is involved in its degradation.The substrates of Plk1, beyond the functions in mitosis.Role of E3 ubiquitin ligases in lung cancer.The E3 ligase Topors induces the accumulation of polysumoylated forms of DNA topoisomerase I in vitro and in vivo.Novel potential ALL low-risk markers revealed by gene expression profiling with new high-throughput SSH-CCS-PCR.
P2860
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P2860
Identification of a novel gene encoding a p53-associated protein
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Identification of a novel gene encoding a p53-associated protein
@ast
Identification of a novel gene encoding a p53-associated protein
@en
Identification of a novel gene encoding a p53-associated protein
@nl
type
label
Identification of a novel gene encoding a p53-associated protein
@ast
Identification of a novel gene encoding a p53-associated protein
@en
Identification of a novel gene encoding a p53-associated protein
@nl
prefLabel
Identification of a novel gene encoding a p53-associated protein
@ast
Identification of a novel gene encoding a p53-associated protein
@en
Identification of a novel gene encoding a p53-associated protein
@nl
P921
P1433
P1476
Identification of a novel gene encoding a p53-associated protein
@en
P304
P356
10.1016/S0378-1119(99)00203-6
P407
P50
P577
1999-07-01T00:00:00Z