Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein
about
topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damageTopors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophyThe Drosophila STUbL protein Degringolade limits HES functions during embryogenesis.Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, ToporsDegringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression.Nuclear structure and chromosome segregation in Drosophila male meiosis depend on the ubiquitin ligase dTopors.Stimulation of in vitro sumoylation by Slx5-Slx8: evidence for a functional interaction with the SUMO pathwayCoping with stress: multiple ways to activate p53.A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning.
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P2860
Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein
description
2004 nî lūn-bûn
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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2004 թվականի ապրիլին հրատարակված գիտական հոդված
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2004年の論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年论文
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name
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@ast
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@en
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@en-gb
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@nl
type
label
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@ast
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@en
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@en-gb
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@nl
prefLabel
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@ast
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@en
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@en-gb
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@nl
P2860
P921
P356
P1476
Drosophila Topors is a RING fi ...... x-loop-helix repressor protein
@en
P2093
Julie Secombe
P2860
P304
P356
10.1074/JBC.M310097200
P407
P577
2004-04-23T00:00:00Z