The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate
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Exome sequencing and functional analysis identifies a novel mutation in EXT1 gene that causes multiple osteochondromasMultiple osteochondromasMolecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfaGolgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesisIn vitro polymerization of heparan sulfate backbone by the EXT proteinsIdentification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycansThe EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivoHuman tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesisGolgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilotThe link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteinsGenotype-phenotype correlation in hereditary multiple exostosesDeterminants of Glycosaminoglycan (GAG) StructurePathophysiology of heparan sulphate: many diseases, few drugsHuman genetic disorders and knockout mice deficient in glycosaminoglycanHeparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myelomaThe components of the Saccharomyces cerevisiae mannosyltransferase complex M-Pol I have distinct functions in mannan synthesis.Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfationDiminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytesThe donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residuesConstruction of a natural panel of 11p11.2 deletions and further delineation of the critical region involved in Potocki-Shaffer syndromeCharacterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathiesHeparin/heparan sulfate biosynthesis: processive formation of N-sulfated domainsFunctional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegansMice deficient in Ext2 lack heparan sulfate and develop exostosesCloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimeraseMutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome.Heparan sulfate: lessons from knockout miceFunctional states of homooligomers: insights from the evolution of glycosyltransferases.Heparan sulfate biosynthesis: methods for investigation of the heparanosomeHerpes simplex virus: discovering the link between heparan sulphate and hereditary bone tumours.EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay.Investigating the elusive mechanism of glycosaminoglycan biosynthesis.A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.Multiple osteochondromas: clinicopathological and genetic spectrum and suggestions for clinical management.Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells.rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses.Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systemsEtiological point mutations in the hereditary multiple exostoses gene EXT1: a functional analysis of heparan sulfate polymerase activity
P2860
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P248
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P2860
The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate
description
2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2000 թվականի հունվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
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2000年論文
@zh-mo
2000年論文
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2000年论文
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name
The putative tumor suppressors ...... e synthesis of heparan sulfate
@ast
The putative tumor suppressors ...... e synthesis of heparan sulfate
@en
The putative tumor suppressors ...... e synthesis of heparan sulfate
@en-gb
The putative tumor suppressors ...... e synthesis of heparan sulfate
@nl
type
label
The putative tumor suppressors ...... e synthesis of heparan sulfate
@ast
The putative tumor suppressors ...... e synthesis of heparan sulfate
@en
The putative tumor suppressors ...... e synthesis of heparan sulfate
@en-gb
The putative tumor suppressors ...... e synthesis of heparan sulfate
@nl
prefLabel
The putative tumor suppressors ...... e synthesis of heparan sulfate
@ast
The putative tumor suppressors ...... e synthesis of heparan sulfate
@en
The putative tumor suppressors ...... e synthesis of heparan sulfate
@en-gb
The putative tumor suppressors ...... e synthesis of heparan sulfate
@nl
P2093
P2860
P921
P3181
P356
P1476
The putative tumor suppressors ...... e synthesis of heparan sulfate
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.97.2.668
P407
P577
2000-01-18T00:00:00Z