The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins - Wikidata - awgldk - TriplyDB

The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins

The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins

http://www.wikidata.org/entity/Q24671153

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Exome sequencing and functional analysis identifies a novel mutation in EXT1 gene that causes multiple osteochondromas XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32)MicroRNA profiling of multiple osteochondromas: identification of disease-specific and normal cartilage signatures Pancreatic reg I binds MKP-1 and regulates cyclin D in pancreatic-derived cells Heparan sulfate: lessons from knockout mice A pectin glucuronyltransferase gene is essential for intercellular attachment in the plant meristem.Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher.Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects.Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation Defective initiation of glycosaminoglycan synthesis due to B3GALT6 mutations causes a pleiotropic Ehlers-Danlos-syndrome-like connective tissue disorder.Molecular diversity of heparan sulfate.The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated.Plant cell adhesion: a bioassay facilitates discovery of the first pectin biosynthetic gene.Molecular-pathogenetic classification of genetic disorders of the skeleton.Mammalian heparanase: what is the message?Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume Evolution of glycosaminoglycans and their glycosyltransferases: Implications for the extracellular matrices of animals and the capsules of pathogenic bacteria.Identification of a novel EXT1 mutation in patients with hereditary multiple exostosis by exome sequencing Developmental pathways in musculoskeletal neoplasia: involvement of the Indian Hedgehog-parathyroid hormone-related protein pathway.Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function.Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans.Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest Of hedgehogs and hereditary bone tumors: re-examination of the pathogenesis of osteochondromas.Heparan sulfate regulates ephrin-A3/EphA receptor signaling.Perlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.The skeletal manifestations of the congenital disorders of glycosylation.Rare monogenetic syndromes in rheumatology practice.Novel mutation of EXT2 identified in a large family with multiple osteochondromas Glycosaminoglycan polysaccharide biosynthesis and production: today and tomorrow.Epigenetic Regulation of the Biosynthesis & Enzymatic Modification of Heparan Sulfate Proteoglycans: Implications for Tumorigenesis and Cancer Biomarkers.Glycosaminoglycan overproduction in the aorta increases aortic calcification in murine chronic kidney disease.Regulation of xylosyltransferase I gene expression by interleukin 1β in human primary chondrocyte cells: mechanism and impact on proteoglycan synthesis.Anatomical variation of co-existence of 4th and 5th short metacarpal bones, sesamoid ossicles and exostoses of ulna and radius in the same hand: a case report.New mutations of EXT1 and EXT2 genes in German patients with Multiple Osteochondromas.Peripheral chondrosarcoma progression is accompanied by decreased Indian Hedgehog signalling.Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling.Bioactive hydrogels for bone regeneration.

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P2860

The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins

http://www.wikidata.org/entity/Q24671153

description

2001 nî lūn-bûn

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2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2001 թվականի օգոստոսին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年论文

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name

The link between heparan sulfa ...... tive tumor suppressor proteins

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The link between heparan sulfa ...... tive tumor suppressor proteins

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The link between heparan sulfa ...... tive tumor suppressor proteins

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type

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The link between heparan sulfa ...... tive tumor suppressor proteins

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The link between heparan sulfa ...... tive tumor suppressor proteins

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The link between heparan sulfa ...... tive tumor suppressor proteins

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The link between heparan sulfa ...... tive tumor suppressor proteins

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The link between heparan sulfa ...... tive tumor suppressor proteins

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The link between heparan sulfa ...... tive tumor suppressor proteins

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The link between heparan sulfa ...... tive tumor suppressor proteins

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P2860

The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation

A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis

Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)

Identification and localization of the gene for EXTL, a third member of the multiple exostoses gene family

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.

The structure of the human multiple exostoses 2 gene and characterization of homologs in mouse and Caenorhabditis elegans

Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis

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