The spontaneous appearance rate of the yeast prion [PSI+] and its implications for the evolution of the evolvability properties of the [PSI+] system
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Prions, protein homeostasis, and phenotypic diversityRobustness and evolvabilityActin, Membrane Trafficking and the Control of Prion Induction, Propagation and Transmission in YeastSup35 methionine oxidation is a trigger for de novo [PSI(+)] prion formationThe [RNQ+] prion: a model of both functional and pathological amyloidRebels with a cause: molecular features and physiological consequences of yeast prionsSpontaneous variants of the [RNQ+] prion in yeast demonstrate the extensive conformational diversity possible with prion proteinsDe novo [PSI +] prion formation involves multiple pathways to form infectious oligomers.Investigating the interactions of yeast prions: [SWI+], [PSI+], and [PIN+].Prion propagation can occur in a prokaryote and requires the ClpB chaperone.Prions are a common mechanism for phenotypic inheritance in wild yeasts.The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.Does the central dogma still stand?The relationship between relative solvent accessibility and evolutionary rate in protein evolution.Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins.Increasing prion propensity by hydrophobic insertion.Pernicious pathogens or expedient elements of inheritance: the significance of yeast prions.Newly identified prions in budding yeast, and their possible functions.Heterologous aggregates promote de novo prion appearance via more than one mechanism.The sensitive [SWI (+)] prion: new perspectives on yeast prion diversity.Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism.On the Nature and Evolutionary Impact of Phenotypic Robustness Mechanisms.The ribosome-associated complex antagonizes prion formation in yeast.Prions in yeast.Emergence and natural selection of drug-resistant prions.Patterns of [PSI (+) ] aggregation allow insights into cellular organization of yeast prion aggregates.The frequency of yeast [PSI+] prion formation is increased during chronological ageing.Analysis of [SWI+ ] formation and propagation events.Prion-like proteins and their computational identification in proteomes.Extensive diversity of prion strains is defined by differential chaperone interactions and distinct amyloidogenic regions.Methionine oxidation of Sup35 protein induces formation of the [PSI+] prion in a yeast peroxiredoxin mutant.Oxidative stress conditions increase the frequency of de novo formation of the yeast [PSI+] prion.Toxicity and infectivity: insights from de novo prion formation.An evolutionarily conserved prion-like element converts wild fungi from metabolic specialists to generalists.Autophagy protects against de novo formation of the [PSI+] prion in yeastA size threshold limits prion transmission and establishes phenotypic diversity.The [PSI +] yeast prion does not wildly affect proteome composition whereas selective pressure exerted on [PSI +] cells can promote aneuploidy.Generation of prions in vitro and the protein-only hypothesis.Could yeast prion domains originate from polyQ/N tracts?Spatial sequestration and oligomer remodeling during de novo [PSI+] formation.
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P2860
The spontaneous appearance rate of the yeast prion [PSI+] and its implications for the evolution of the evolvability properties of the [PSI+] system
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2010 nî lūn-bûn
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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The spontaneous appearance rat ...... roperties of the [PSI+] system
@ast
The spontaneous appearance rat ...... roperties of the [PSI+] system
@en
The spontaneous appearance rat ...... roperties of the [PSI+] system
@en-gb
The spontaneous appearance rat ...... roperties of the [PSI+] system
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type
label
The spontaneous appearance rat ...... roperties of the [PSI+] system
@ast
The spontaneous appearance rat ...... roperties of the [PSI+] system
@en
The spontaneous appearance rat ...... roperties of the [PSI+] system
@en-gb
The spontaneous appearance rat ...... roperties of the [PSI+] system
@nl
prefLabel
The spontaneous appearance rat ...... roperties of the [PSI+] system
@ast
The spontaneous appearance rat ...... roperties of the [PSI+] system
@en
The spontaneous appearance rat ...... roperties of the [PSI+] system
@en-gb
The spontaneous appearance rat ...... roperties of the [PSI+] system
@nl
P2860
P1433
P1476
The spontaneous appearance rat ...... roperties of the [PSI+] system
@en
P2093
Heather L True
J Patrick Bardill
P2860
P304
P356
10.1534/GENETICS.109.110213
P407
P577
2009-11-16T00:00:00Z