Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis
about
The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CADPhosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesisDivergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeastsCrystal structure of Escherichia coli cytidine triphosphate synthetase, a nucleotide-regulated glutamine amidotransferase/ATP-dependent amidoligase fusion protein and homologue of anticancer and antiparasitic drug targetsLeflunomide: mode of action in the treatment of rheumatoid arthritisTranscriptional repression of human cad gene by hypoxia inducible factor-1alphaStructure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesisStructural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical ScaffoldsStructural determinants for the inhibitory ligands of orotidine-5′-monophosphate decarboxylaseNovel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse ModelThe Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled OligomerizationStructure of Salmonella typhimurium OMP Synthase in a Complete Substrate ComplexCrystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylaseMissense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesisOrotic aciduria and uridine monophosphate synthase: a reappraisalComplete inhibition of dihydro-orotate oxidation and superoxide production by 1,1,1-trifluoro-3-thenoylacetone in rat liver mitochondriaRegulation of carbamoyl phosphate synthetase by MAP kinaseThe effect of glutamine concentration on the activity of carbamoyl-phosphate synthase II and on the incorporation of [3H]thymidine into DNA in rat mesenteric lymphocytes stimulated by phytohaemagglutininRegulation by insulin of liver carbamoyl-phosphate synthase II (glutamine-hydrolysing)Analysis of the Zebrafish perplexed mutation reveals tissue-specific roles for de novo pyrimidine synthesis during development.The yeast Cdc8 exhibits both deoxythymidine monophosphate and diphosphate kinase activitiesPhosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.Construction of a cDNA to the hamster CAD gene and its application toward defining the domain for aspartate transcarbamylase.Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth.Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum.A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cellsAnalysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase.Evidence for an inducible repair-recombination system in the female germ line of Drosophila melanogaster. I. Induction by inhibitors of nucleotide synthesis and by gamma rays.Functional expression and characterization of the two cyclic amidohydrolase enzymes, allantoinase and a novel phenylhydantoinase, from Escherichia coliElectrophilic aromatic selenylation: new OPRT inhibitors.Leaving group activation and pyrophosphate ionic state at the catalytic site of Plasmodium falciparum orotate phosphoribosyltransferase.Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster.Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) acIdentification and functional analysis of the erh1(+) gene encoding enhancer of rudimentary homolog from the fission yeast Schizosaccharomyces pombeA dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants.Substrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenaseIdentification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)Identification of amino acid residues of ERH required for its recruitment to nuclear speckles and replication foci in HeLa cellsAnti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis.Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice
P2860
Q24301815-11694217-F826-48AB-9A32-58E6805738A3Q24555786-55731D50-36EB-474D-B33D-D38534CACACFQ24563845-69F0FD39-3DB5-4082-B04E-6AE4E4998409Q24629725-63DAA0BD-9A7A-47D7-A3D2-43E2714AA5EBQ24675005-0B1B427C-D4CB-4D15-AAD2-EFD7F7F04576Q24814445-6A7A5FE4-F096-4932-AE71-9B920CAE367EQ27305337-7C9879C0-207C-4BEB-93AD-F3FAE7C8663DQ27656755-86BA36D2-3F96-4BB8-AE11-C458285340D8Q27661430-9F8C0B6E-2B16-4CBF-A310-1E35749B85E0Q27664030-1EAD15A2-7974-4CFC-8F74-8E5BD7B63100Q27667488-A7F588FC-BDE3-450D-9691-19DB7DDB2438Q27678717-BB506CF9-2FA9-4206-8E53-5E15FD40F60DQ27679377-C9BDC813-20E7-4EE8-9442-70DB5C37D522Q28115898-45F7231F-C044-4A9F-9937-FB88C2B98F6BQ28250181-86AEFC1F-DE42-41F7-A595-6EC7307F48FCQ28360253-C70BFC85-A9A3-41CA-9694-AE59AD694060Q28578262-9C8C0CC1-AD61-41E0-BACF-CA8B14EBAF62Q28579304-DBDFFAE7-05AA-4A38-9AD1-98156A90B279Q28584266-23F27D7D-C2F6-4080-9029-AF25B4AA3EB4Q28768108-0309598B-C003-44C9-BD56-0CA2D50B4825Q28909271-2715A4EA-40CF-4AA8-B24F-0186AF0BE984Q30396867-7FA11258-7943-4B77-AC94-C9526916664AQ30403099-B53F9FC0-BD26-43F8-9DB0-696C868BF9D7Q33258023-D0004351-2020-490C-A54C-C69593BFDF52Q33567066-FD449154-3A4E-4CF6-9717-74A73995770CQ33667520-29BE883C-986C-4FDE-AFE9-4F7C3992B81CQ33844680-0E28FEAC-A5A0-4CC9-BDA5-C04A2DE29699Q33965844-CDAF9C0D-56A9-4D3C-B39B-5036BF74143DQ33995075-256B469A-B726-4B99-B428-6806AA99544DQ34118910-31F533F9-34FD-4456-A467-7B27B0556086Q34149050-33B438D6-1BD6-451E-9058-C544F57017CFQ34290448-BD9B6720-D282-4CA0-84A7-DB96DA67AF34Q34449367-A1F0F2FB-AEDF-4585-8234-972588D277FDQ34473960-88C9975F-AB1D-469F-9054-0D51392B2130Q34604054-C8AEF48F-B41F-4435-86B2-2D975349DA42Q34801146-D66D2E7D-EDDA-417E-8A2C-7362BA1761F4Q34881218-12E37D0B-1C9D-478F-82B9-FF36A0657DA1Q34981802-239962CB-C4D9-499E-9A11-B2AF7D9B1FA6Q35552561-2AA4AACB-C228-4440-891D-CBBFEB751C55Q35565199-BDF5B80E-F34E-4A2D-9F1E-902F5F56BE17
P2860
Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis
description
1980 nî lūn-bûn
@nan
1980 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1980 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1980年の論文
@ja
1980年論文
@yue
1980年論文
@zh-hant
1980年論文
@zh-hk
1980年論文
@zh-mo
1980年論文
@zh-tw
1980年论文
@wuu
name
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@ast
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@en
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@en-gb
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@nl
type
label
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@ast
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@en
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@en-gb
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@nl
altLabel
Pyrimidine nucleotide biosynth ...... regulation of UMP biosynthesis
@en
prefLabel
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@ast
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@en
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@en-gb
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@nl
P1476
Pyrimidine Nucleotide Biosynth ...... Regulation of UMP Biosynthesis
@en
P2093
P304
P356
10.1146/ANNUREV.BI.49.070180.001345
P407
P577
1980-06-01T00:00:00Z