Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
about
Contribution of horizontal gene transfer to the evolution of Saccharomyces cerevisiaeAnaerobic xylose fermentation by recombinant Saccharomyces cerevisiae carrying XYL1, XYL2, and XKS1 in mineral medium chemostat cultures.Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical ScaffoldsEnzymatic activities of Ura2 and Ura1 proteins (aspartate carbamoyltransferase and dihydro-orotate dehydrogenase) are present in both isolated membranes and cytoplasm of Saccharomyces cerevisiae.Activation of transcription by metabolic intermediates of the pyrimidine biosynthetic pathway.Being right on Q: shaping eukaryotic evolutionProteomic analysis of carbon concentrating chemolithotrophic bacteria Serratia sp. for sequestration of carbon dioxideAbility for anaerobic growth is not sufficient for development of the petite phenotype in Saccharomyces kluyveriGene responses to oxygen availability in Kluyveromyces lactis: an insight on the evolution of the oxygen-responding system in yeast.Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase.Amiloride uptake and toxicity in fission yeast are caused by the pyridoxine transporter encoded by bsu1+ (car1+).Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.The evolution of aerobic fermentation in Schizosaccharomyces pombe was associated with regulatory reprogramming but not nucleosome reorganization.Dynamic flux balance analysis of the metabolism of Saccharomyces cerevisiae during the shift from fully respirative or respirofermentative metabolic states to anaerobiosis.Yeast "make-accumulate-consume" life strategy evolved as a multi-step process that predates the whole genome duplication.A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants.Polypeptone induces dramatic cell lysis in ura4 deletion mutants of fission yeastSubstrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenaseNMR-based stable isotope resolved metabolomics in systems biochemistry.Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenasePurification and characterization of dihydroorotate dehydrogenase A from Lactococcus lactis, crystallization and preliminary X-ray diffraction studies of the enzymeThe dimeric dihydroorotate dehydrogenase A from Lactococcus lactis dissociates reversibly into inactive monomers.Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.Model-driven analysis of experimentally determined growth phenotypes for 465 yeast gene deletion mutants under 16 different conditions.Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in miceThe sequence and binding specificity of UaY, the specific regulator of the purine utilization pathway in Aspergillus nidulans, suggest an evolutionary relationship with the PPR1 protein of Saccharomyces cerevisiae.The regulation of coenzyme q biosynthesis in eukaryotic cells: all that yeast can tell us.Oxygen requirements of the food spoilage yeast Zygosaccharomyces bailii in synthetic and complex media.Anaerobic α-amylase production and secretion with fumarate as the final electron acceptor in Saccharomyces cerevisiae.Two different dihydroorotate dehydrogenases in Lactococcus lactis.Recombinant production, crystallization and crystal structure determination of dihydroorotate dehydrogenase from Leishmania (Viannia) braziliensis.Insights into the mechanism of oxidation of dihydroorotate to orotate catalysed by human class 2 dihydroorotate dehydrogenase: a QM/MM free energy study.Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide.Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo.De Novo Pyrimidine Biosynthesis Connects Cell Integrity to Amphotericin B Susceptibility in Cryptococcus neoformans.b-type dihydroorotate dehydrogenase is purified as a H2O2-forming NADH oxidase from Bifidobacterium bifidum.Disruption of the proton relay network in the class 2 dihydroorotate dehydrogenase from Escherichia coli.Divergent evolution of a beta/alpha-barrel subclass: detection of numerous phosphate-binding sites by motif search.
P2860
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P2860
Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
description
1992 nî lūn-bûn
@nan
1992 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
@ast
Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
@en
Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
@nl
type
label
Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
@ast
Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
@en
Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
@nl
prefLabel
Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
@ast
Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
@en
Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
@nl
P2093
P2860
P921
P3181
P356
P1476
Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.89.19.8966
P407
P577
1992-10-01T00:00:00Z