Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding
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Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitmentCharacterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEFIdentification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeletonFrequent mutation of histone-modifying genes in non-Hodgkin lymphomaSmall GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblastsActivated RhoA Binds to the Pleckstrin Homology (PH) Domain of PDZ-RhoGEF, a Potential Site for AutoregulationIdentification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain ComplexPalmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signallingPalmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residueRGS16 inhibits signalling through the G alpha 13-Rho axisRegulation of G proteins by covalent modificationRegulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinaseOn the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factorCCK activates RhoA and Rac1 differentially through Galpha13 and Galphaq in mouse pancreatic acini.Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF.Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).Autoinhibition mechanism of proto-Dbl.Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cellsSignalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia.A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis.Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid raftsWNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy.Regulation and physiological functions of G12/13-mediated signaling pathways.Gα12 structural determinants of Hsp90 interaction are necessary for serum response element-mediated transcriptional activation.G protein trafficking.MicroRNA-132, -134, and -138: a microRNA troika rules in neuronal dendrites.Understanding Protein Palmitoylation: Biological Significance and EnzymologyAssociation of N-cadherin levels and downstream effectors of Rho GTPases with dendritic spine loss induced by chronic stress in rat hippocampal neurons.Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEFChimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13.Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF.A Gα12-specific Binding Domain in AKAP-Lbc and p114RhoGEF.Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.MicroRNA-mediated regulation of synaptic palmitoylation: shrinking fat spines.Epigallocatechin-3-gallate treatment reduces thermal hyperalgesia after spinal cord injury by down-regulating RhoA expression in mice.
P2860
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P2860
Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
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2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@ast
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@en
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@en-gb
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@nl
type
label
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@ast
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@en
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@en-gb
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@nl
prefLabel
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@ast
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@en
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@en-gb
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@nl
P356
P1476
Galpha 13 requires palmitoylat ...... f p115-RhoGEF membrane binding
@en
P2093
P B Wedegaertner
R Bhattacharyya
P304
P356
10.1074/JBC.M000415200
P407
P577
2000-05-19T00:00:00Z