about
A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domainNm23-H1 modulates the activity of the guanine exchange factor Dbl-1The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesisAsef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation elementIdentification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeletonRHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegansThe Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor IntersectinAKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formationRegulation of proto-Dbl by intracellular membrane targeting and protein stabilityRegulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinaseCharacterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPasesThe A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophyDefective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl.Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with DblRegulation of vesicle transport and cell motility by Golgi-localized Dbs.Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions.On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.Leucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP-Lbc.LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity.Tyrosine phosphorylation of Dbl regulates GTPase signalingModification of p115RhoGEF Ser(330) regulates its RhoGEF activity.The BNIP-2 and Cdc42GAP homology (BCH) domain of p50RhoGAP/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-activating protein domain.Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.Signaling to the Rho GTPases: networking with the DH domain.Intramolecular interactions between the Dbl homology (DH) domain and the carboxyl-terminal region of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) act as an autoinhibitory mechanism for the regulation of MyoGEF functions.Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.Activation of Dbl restores migration in polyamine-depleted intestinal epithelial cells via Rho-GTPases.Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation.The nucleotide exchange factor Cdc24p may be regulated by auto-inhibition.Growth arrest-inducing genes are activated in Dbl-transformed mouse fibroblasts.Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation.HSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain.p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr.High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice.Regulation of the Dbl proto-oncogene by heat shock cognate protein 70 (Hsc70).The Rho exchange factor Net1 is regulated by nuclear sequestration.Oligomerization regulates the localization of Cdc24, the Cdc42 activator in Saccharomyces cerevisiae.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Autoinhibition mechanism of proto-Dbl.
@ast
Autoinhibition mechanism of proto-Dbl.
@en
type
label
Autoinhibition mechanism of proto-Dbl.
@ast
Autoinhibition mechanism of proto-Dbl.
@en
prefLabel
Autoinhibition mechanism of proto-Dbl.
@ast
Autoinhibition mechanism of proto-Dbl.
@en
P2093
P2860
P1476
Autoinhibition mechanism of proto-Dbl
@en
P2093
P2860
P304
P356
10.1128/MCB.21.5.1463-1474.2001
P407
P577
2001-03-01T00:00:00Z