Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
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Structural basis for fibroblast growth factor receptor 2 activation in Apert syndromeStructural basis by which alternative splicing confers specificity in fibroblast growth factor receptorsGentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitorsStructural basis by which alternative splicing modulates the organizer activity of FGF8 in the brainInsights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuityFibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFsTissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signalingNovel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1Fibroblast growth factorsIdentification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesisAnalysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerizationThe alternatively spliced acid box region plays a key role in FGF receptor autoinhibitionBetaKlotho is required for metabolic activity of fibroblast growth factor 21Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily membersThe role of FGF signaling in guiding coordinate movement of cell groups: guidance cue and cell adhesion regulator?Exploring mechanisms of FGF signalling through the lens of structural biologyCrystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibitionStructure and stability of an acidic fibroblast growth factor from Notophthalmus viridescensNMR solution structures of delta-conotoxin EVIA from Conus ermineus that selectively acts on vertebrate neuronal Na+ channelsStructure of rat acidic fibroblast growth factor at 1.4 Å resolutionHomodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular MatrixX-ray structure and biophysical properties of rabbit fibroblast growth factor 1Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1Fibroblast growth factor signaling in Caenorhabditis elegansN-glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co-receptor bindingMolecular mechanisms of fibroblast growth factor signaling in physiology and pathologyIn-frame amber stop codon replacement mutagenesis for the directed evolution of proteins containing non-canonical amino acids: identification of residues open to bio-orthogonal modificationParallelism and Epistasis in Skeletal Evolution Identified through Use of Phylogenomic Mapping StrategiesNMR structure of the first Ig module of mouse FGFR1Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction.FGF5 is a crucial regulator of hair length in humansDecrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 geneCompositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor.fibroblast growth factor receptor complexesIsolation of a novel basic FGF-binding peptide with potent antiangiogenetic activity.Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expressionFGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.Interrogating protein interaction networks through structural biologyA deletion of FGFR2 creating a chimeric IIIb/IIIc exon in a child with Apert syndromeBiochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities.
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P2860
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Crystal structures of two FGF- ...... of ligand-receptor specificity
@ast
Crystal structures of two FGF- ...... of ligand-receptor specificity
@en
Crystal structures of two FGF- ...... of ligand-receptor specificity
@en-gb
Crystal structures of two FGF- ...... of ligand-receptor specificity
@nl
type
label
Crystal structures of two FGF- ...... of ligand-receptor specificity
@ast
Crystal structures of two FGF- ...... of ligand-receptor specificity
@en
Crystal structures of two FGF- ...... of ligand-receptor specificity
@en-gb
Crystal structures of two FGF- ...... of ligand-receptor specificity
@nl
prefLabel
Crystal structures of two FGF- ...... of ligand-receptor specificity
@ast
Crystal structures of two FGF- ...... of ligand-receptor specificity
@en
Crystal structures of two FGF- ...... of ligand-receptor specificity
@en-gb
Crystal structures of two FGF- ...... of ligand-receptor specificity
@nl
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Crystal structures of two FGF- ...... of ligand-receptor specificity
@en
P2093
A N Plotnikov
J Schlessinger
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P3181
P356
10.1016/S0092-8674(00)80851-X
P407
P577
2000-05-01T00:00:00Z