Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
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The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effectStructural basis by which alternative splicing confers specificity in fibroblast growth factor receptorsAnalysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerizationReceptor specificity of the fibroblast growth factor family. The complete mammalian FGF familyA Genetic-Pathophysiological Framework for CraniosynostosisFibroblast growth factor signaling in skeletal development and diseasePlasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1Molecular mechanisms of fibroblast growth factor signaling in physiology and pathologyEvidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse modelDevelopmental and Evolutionary Significance of the Zygomatic BoneARS-interacting multi-functional protein 1 induces proliferation of human bone marrow-derived mesenchymal stem cells by accumulation of β-catenin via fibroblast growth factor receptor 2-mediated activation of AktPredicting the impact of deleterious mutations in the protein kinase domain of FGFR2 in the context of function, structure, and pathogenesis--a bioinformatics approach.Compositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor.fibroblast growth factor receptor complexesActivation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice.Quantification of facial skeletal shape variation in fibroblast growth factor receptor-related craniosynostosis syndromes.Role of FGFR2-signaling in the pathogenesis of acne.Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogoniaFrequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes.The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm.Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongationA deletion of FGFR2 creating a chimeric IIIb/IIIc exon in a child with Apert syndromeFGF/FGFR signaling coordinates skull development by modulating magnitude of morphological integration: evidence from Apert syndrome mouse modelsBiochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities.Beyond the closed suture in apert syndrome mouse models: evidence of primary effects of FGFR2 signaling on facial shape at birth.Structural basis for activation of fibroblast growth factor signaling by sucrose octasulfateInvestigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation.The Fibroblast Growth Factor signaling pathwayLoss-of-function fibroblast growth factor receptor-2 mutations in melanomaMolecular basis of cranial suture biology and disease: Osteoblastic and osteoclastic perspectivesRelation of FGFR2 genetic polymorphisms to the association between oral contraceptive use and the risk of breast cancer in Chinese women.FGFs, their receptors, and human limb malformations: clinical and molecular correlations.Inhibited Wnt signaling causes age-dependent abnormalities in the bone matrix mineralization in the Apert syndrome FGFR2(S252W/+) miceActual concepts in scaphocephaly : (an experience of 98 cases).A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts.Molecular analysis of exons 8, 9 and 10 of the fibroblast growth factor receptor 2 (FGFR2) gene in two families with index cases of Apert SyndromeFrom shape to cells: mouse models reveal mechanisms altering palate development in Apert syndromeSyndromic craniosynostosis: from history to hydrogen bonds.Molecular Analysis of Twist1 and FGF Receptors in a Rabbit Model of Craniosynostosis: Likely Exclusion as the Loci of OriginThe FGF family: biology, pathophysiology and therapyUnderstanding craniosynostosis as a growth disorder
P2860
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P2860
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@ast
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@en
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@en-gb
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@nl
type
label
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@ast
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@en
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@en-gb
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@nl
prefLabel
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@ast
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@en
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@en-gb
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@nl
P2093
P2860
P356
P1476
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
@en
P2093
A N Plotnikov
A V Eliseenkova
D M Ornitz
O A Ibrahimi
P2860
P304
P356
10.1073/PNAS.121183798
P407
P577
2001-06-19T00:00:00Z