The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death
about
Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBPPbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cellsUXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformationThe leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylaseOverexpression of EVI1 interferes with cytokinesis and leads to accumulation of cells with supernumerary centrosomes in G0/1 phase.Arsenic trioxide induces apoptosis in the THP1 cell line by downregulating EVI-1Acetylation of the proto-oncogene EVI1 abrogates Bcl-xL promoter binding and induces apoptosisRole of regulatory elements and the MAPK/ERK or p38 MAPK pathways for activation of human cytomegalovirus gene expression.Rearrangements of chromosome band 3q21 in myeloid leukemia.EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cellsGlobal Identification of EVI1 Target Genes in Acute Myeloid Leukemia.Role of AML1/Runx1 in the pathogenesis of hematological malignancies.EVI1, a target gene for amplification at 3q26, antagonizes transforming growth factor-β-mediated growth inhibition in hepatocellular carcinoma.The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia.RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells.EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylationEvi1 forms a bridge between the epigenetic machinery and signaling pathways.PRDM proteins: important players in differentiation and disease.What have we learned from murine models of otitis media?EVI1 promotes tumor growth via transcriptional repression of MS4A3.EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis.Enhanced sensitivity to hydrogen peroxide-induced apoptosis in Evi1 transformed Rat1 fibroblasts due to repression of carbonic anhydrase III.Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer.Point mutations in two EVI1 Zn fingers abolish EVI1-GATA1 interaction and allow erythroid differentiation of murine bone marrow cells.EVI1 and MDS1/EVI1 expression during primary human hematopoietic progenitor cell differentiation into various myeloid lineages.Myringotomy in the Junbo mouse model of chronic otitis media alleviates inflammation and cellular hypoxia.Intratumoral Heterogeneity of Frameshift Mutations in MECOM Gene is Frequent in Colorectal Cancers with High Microsatellite Instability.Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes.The Evi1 proto-oncoprotein blocks endomitosis in megakaryocytes by inhibiting sustained cyclin-dependent kinase 2 catalytic activity.The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity.Leukemia-related transcription factor TEL is negatively regulated through extracellular signal-regulated kinase-induced phosphorylationThe t(3;21) fusion product, AML1/Evi-1 blocks AML1-induced transactivation by recruiting CtBP.The oncogene EVI1 enhances transcriptional and biological responses of human myeloid cells to all-trans retinoic acid.Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.Expression of MECOM is associated with unfavorable prognosis in glioblastoma multiforme.EVI-1 modulates leukemogenic potential and apoptosis sensitivity in human acute lymphoblastic leukemia.Multigene pathway-based analyses identify nasopharyngeal carcinoma risk associations for cumulative adverse effects of TERT-CLPTM1L and DNA double-strand breaks repair.RUNX1/EVI1, which blocks myeloid differentiation, inhibits CCAAT-enhancer binding protein alpha function.
P2860
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P2860
The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death
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2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2000 թվականի հունիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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The evi-1 oncoprotein inhibits ...... ents stress-induced cell death
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The evi-1 oncoprotein inhibits ...... ents stress-induced cell death
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The evi-1 oncoprotein inhibits ...... ents stress-induced cell death
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Kurokawa M
Yamagata T
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10.1093/EMBOJ/19.12.2958
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P577
2000-06-01T00:00:00Z