sameAs
Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sitesMolecular targets underlying general anaesthesiaTwo-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channelsThe alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effectsCompetitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates xenon neuroprotection against hypoxia-ischemiaFatty acid binding to human serum albumin: new insights from crystallographic studiesStaying awake--a genetic region that hinders α2 adrenergic receptor agonist-induced sleep.Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection.Altered activity in the central medial thalamus precedes changes in the neocortex during transitions into both sleep and propofol anesthesia.Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane.Neuroprotection against traumatic brain injury by xenon, but not argon, is mediated by inhibition at the N-methyl-D-aspartate receptor glycine site.A propofol binding site on mammalian GABAA receptors identified by photolabelingModerate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial.The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study.Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology.An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action.Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics.Wakefulness Is Governed by GABA and Histamine Cotransmission.The TREK K2P channels and their role in general anaesthesia and neuroprotection.Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.Xenon improves neurologic outcome and reduces secondary injury following trauma in an in vivo model of traumatic brain injury.Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs?GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousnessRole of endogenous sleep-wake and analgesic systems in anesthesia.General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal.Modulation of the general anesthetic sensitivity of a protein: a transition between two forms of firefly luciferase.Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons.Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABAA Receptors with Different γ Subunits.Sleep and general anesthesia.The role of K₂p channels in anaesthesia and sleep.Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis.Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists.Effects of isoflurane and xenon on Ba2+-currents mediated by N-type calcium channels.The effects of hypoxia on the modulation of human TREK-1 potassium channels.Effects of temperature and volatile anesthetics on GABA(A) receptors.Structural comparisons of ligand-gated ion channels in open, closed, and desensitized states identify a novel propofol-binding site on mammalian γ-aminobutyric acid type A receptors.Actions of general anaesthetics and arachidonic pathway inhibitors on K+ currents activated by volatile anaesthetics and FMRFamide in molluscan neurones.Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol.Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture.General anesthesia and ascending arousal pathways.
P50
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P50
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