Thousands of chemical starting points for antimalarial lead identification
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Data Sharing as Part of the Normal Scientific Process: A View from the Pharmaceutical IndustrySpiroindolones, a potent compound class for the treatment of malariaDrug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drugOpen data in drug discovery and development: lessons from malariaRecent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetasesThe malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugsNext-generation antimicrobials: from chemical biology to first-in-class drugsGlobal phenotypic screening for antimalarialsAn Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and DisciplinesOpen Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos ArylpyrrolesDrug repurposing and human parasitic protozoan diseasesRecent advances in malaria drug discoveryUsing genetic methods to define the targets of compounds with antimalarial activityMalaria in South America: a drug discovery perspectiveThe ChEMBL database as linked open dataEnvironmental constraints guide migration of malaria parasites during transmissionLearning from the past for TB drug discovery in the futureStructure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate PotentialA selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage responseMalarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised targetDesign and Synthesis of Inhibitors of Plasmodium falciparumN -Myristoyltransferase, A Promising Target for Antimalarial Drug DiscoveryMalaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responsesPlasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial HitAntimalarial drug discovery - approaches and progress towards new medicines.Proteochemometric modelling coupled to in silico target prediction: an integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small moleculesOpen Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and BeyondAnalogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivoDiversity-oriented synthesis yields novel multistage antimalarial inhibitorsMutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone AntimalarialsImaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug DiscoveryMapping the genome of Plasmodium falciparum on the drug-like chemical space reveals novel anti-malarial targets and potential drug leadsTargeting Plasmodium PI(4)K to eliminate malariaFosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathwaysAtypical mitogen-activated protein kinase phosphatase implicated in regulating transition from pre-S-Phase asexual intraerythrocytic development of Plasmodium falciparumIn silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discoverySmall molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5Muddled mechanisms: recent progress towards antimalarial target identificationTransmission-blocking strategies: the roadmap from laboratory bench to the communityChEMBL: a large-scale bioactivity database for drug discoveryBiochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
P2860
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P2860
Thousands of chemical starting points for antimalarial lead identification
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Thousands of chemical starting points for antimalarial lead identification
@ast
Thousands of chemical starting points for antimalarial lead identification
@en
Thousands of chemical starting points for antimalarial lead identification
@en-gb
Thousands of chemical starting points for antimalarial lead identification
@nl
type
label
Thousands of chemical starting points for antimalarial lead identification
@ast
Thousands of chemical starting points for antimalarial lead identification
@en
Thousands of chemical starting points for antimalarial lead identification
@en-gb
Thousands of chemical starting points for antimalarial lead identification
@nl
prefLabel
Thousands of chemical starting points for antimalarial lead identification
@ast
Thousands of chemical starting points for antimalarial lead identification
@en
Thousands of chemical starting points for antimalarial lead identification
@en-gb
Thousands of chemical starting points for antimalarial lead identification
@nl
P2093
P921
P3181
P356
P1433
P1476
Thousands of chemical starting points for antimalarial lead identification
@en
P2093
Catherine E. Peishoff
Cristina de Cozar
Dana E. Vanderwall
Darren V. S. Green
Emilio Alvarez
Francisco-Javier Gamo
James R. Brown
Jaume Vidal
Jose-Luis Lavandera
Laura M. Sanz
P2888
P304
P356
10.1038/NATURE09107
P407
P577
2010-05-20T00:00:00Z
P5875
P6179
1009413566