about
Malaria in South America: a drug discovery perspectiveAntimalarial drug discovery - approaches and progress towards new medicines.Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone AntimalarialsProfile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assaysThe open access malaria box: a drug discovery catalyst for neglected diseasesPrediction of the P. falciparum target space relevant to malaria drug discoveryMachine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug DiscoveryBiochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active CompoundsIdentification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity.Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites.Repositioning: the fast track to new anti-malarial medicines?Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum.Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probesFully functionalized small-molecule probes for integrated phenotypic screening and target identification.In vitro activity of fluorescent dyes against asexual blood stages of Plasmodium falciparum.Systems-level antimicrobial drug and drug synergy discovery.In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compoundThe importance of molecular complexity in the design of screening libraries.Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box.Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasitesPotent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target.The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains.Antimalarial drug discovery - the path towards eradication.Plasmodium kinases as targets for new-generation antimalarials.Determination of antiprotozoal drug mechanisms by metabolomics approaches.Chemical profiling of deoxyhypusine hydroxylase inhibitors for antimalarial therapy.Targeting the redox metabolism of Plasmodium falciparum.Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?Metabolomic-based strategies for anti-parasite drug discovery.Antiplasmodial drug targets: a patent review (2000 - 2013).Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action.A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle.Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum.Computational chemistry and drug discovery: a call to action.Virtual-screening workflow tutorials and prospective results from the Teach-Discover-Treat competition 2014 against malaria.Does Plasmodium falciparum have an Achilles' heel?ATP and luciferase assays to determine the rate of drug action in in vitro cultures of Plasmodium falciparum.Biological Studies and Target Engagement of the 2-C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1R,3S)-MMV008138 and Analogs.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Global phenotypic screening for antimalarials
@ast
Global phenotypic screening for antimalarials
@en
Global phenotypic screening for antimalarials
@nl
type
label
Global phenotypic screening for antimalarials
@ast
Global phenotypic screening for antimalarials
@en
Global phenotypic screening for antimalarials
@nl
prefLabel
Global phenotypic screening for antimalarials
@ast
Global phenotypic screening for antimalarials
@en
Global phenotypic screening for antimalarials
@nl
P2093
P2860
P50
P921
P1476
Global phenotypic screening for antimalarials
@en
P2093
Francisco-Javier Gamo
Thierry T Diagana
W Armand Guiguemde
P2860
P304
P356
10.1016/J.CHEMBIOL.2012.01.004
P407
P577
2012-01-01T00:00:00Z