Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactions
about
Activation state-dependent interaction between Galphai and p67phoxA fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis.Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domainsPhosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activationPolarity establishment requires localized activation of Cdc42.Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motifDiverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p.The PB1 domain and the PC motif-containing region are structurally similar protein binding modulesFull-length p40phox structure suggests a basis for regulation mechanism of its membrane bindingThe Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localizationStructural and membrane binding analysis of the Phox homology domain of Bem1p: basis of phosphatidylinositol 4-phosphate specificitySolution Structure of a Novel Cdc42 Binding Module of Bem1 and Its Interaction with Ste20 and Cdc42Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repressionp21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae.A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarizationInteraction codes within the family of mammalian Phox and Bem1p domain-containing proteinsArchitecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phoxStructure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen speciesActivation and assembly of the NADPH oxidase: a structural perspectiveTwo novel proteins activate superoxide generation by the NADPH oxidase NOX1A novel Cdc42-interacting domain of the yeast polarity establishment protein Bem1. Implications for modulation of mating pheromone signaling.Bem1p is a positive regulator of the homotypic fusion of yeast vacuoles.Interactions between Cdc42 and the scaffold protein Scd2: requirement of SH3 domains for GTPase binding.The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.The Cdc42 binding and scaffolding activities of the fission yeast adaptor protein Scd2.A Split-Ubiquitin Based Strategy Selecting for Protein Complex-Interfering MutationsA regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox.Independence of symmetry breaking on Bem1-mediated autocatalytic activation of Cdc42.Small but versatile: the extraordinary functional and structural diversity of the beta-grasp foldMolecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes.Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex.Inhibitory GEF phosphorylation provides negative feedback in the yeast polarity circuitIn silico identification of carboxylate clamp type tetratricopeptide repeat proteins in Arabidopsis and rice as putative co-chaperones of Hsp90/Hsp70iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence.Isolation and characterization of YlBEM1, a gene required for cell polarization and differentiation in the dimorphic yeast Yarrowia lipolytica.Cdc42p-interacting protein Bem4p regulates the filamentous-growth mitogen-activated protein kinase pathway.Central roles of small GTPases in the development of cell polarity in yeast and beyond.The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems.Transcriptome-wide functional characterization reveals novel relationships among differentially expressed transcripts in developing soybean embryos.Relevance of atypical protein kinase C isotypes to the drug discovery process.
P2860
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P2860
Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactions
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Novel modular domain PB1 recog ...... l protein-protein interactions
@ast
Novel modular domain PB1 recog ...... l protein-protein interactions
@en
Novel modular domain PB1 recog ...... l protein-protein interactions
@en-gb
Novel modular domain PB1 recog ...... l protein-protein interactions
@nl
type
label
Novel modular domain PB1 recog ...... l protein-protein interactions
@ast
Novel modular domain PB1 recog ...... l protein-protein interactions
@en
Novel modular domain PB1 recog ...... l protein-protein interactions
@en-gb
Novel modular domain PB1 recog ...... l protein-protein interactions
@nl
prefLabel
Novel modular domain PB1 recog ...... l protein-protein interactions
@ast
Novel modular domain PB1 recog ...... l protein-protein interactions
@en
Novel modular domain PB1 recog ...... l protein-protein interactions
@en-gb
Novel modular domain PB1 recog ...... l protein-protein interactions
@nl
P2093
P2860
P3181
P356
P1433
P1476
Novel modular domain PB1 recog ...... l protein-protein interactions
@en
P2093
P2860
P304
P3181
P356
10.1093/EMBOJ/20.15.3938
P407
P50
P577
2001-08-01T00:00:00Z