Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation
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Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phoxPhosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domainsRegulation of Bin1 SH3 domain binding by phosphoinositidesBiochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular systemRegulation of cell survival and death by pyridine nucleotidesFull-length p40phox structure suggests a basis for regulation mechanism of its membrane bindingStructure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen speciesActivation and assembly of the NADPH oxidase: a structural perspectiveA novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansionZinc wave during the treatment of hypoxia is required for initial reactive oxygen species activation in mitochondriaNovel signaling axis for ROS generation during K-Ras-induced cellular transformationIdentification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation.Trimer hydroxylated quinone derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidaseSpecificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transductionp47phox molecular activation for assembly of the neutrophil NADPH oxidase complex.Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseasesMutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activationRegulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions.Interactions between Cdc42 and the scaffold protein Scd2: requirement of SH3 domains for GTPase binding.A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase.A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox.p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.Gene transfer and expression in human neutrophils. The phox homology domain of p47phox translocates to the plasma membrane but not to the membrane of mature phagosomes.Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes.Evasion of Legionella pneumophila from the bactericidal system by reactive oxygen species (ROS) in macrophages.Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia.Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking.Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production.A conserved region between the TPR and activation domains of p67phox participates in activation of the phagocyte NADPH oxidase.Nox3 regulation by NOXO1, p47phox, and p67phox.Characterization of superoxide overproduction by the D-Loop(Nox4)-Nox2 cytochrome b(558) in phagocytes-Differential sensitivity to calcium and phosphorylation events.Expression and function of Noxo1gamma, an alternative splicing form of the NADPH oxidase organizer 1.Polarity proteins Bem1 and Cdc24 are components of the filamentous fungal NADPH oxidase complex.NADPH oxidase: recent evidence for its role in erectile dysfunction.Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) bindingSubcellular localization and function of alternatively spliced Noxo1 isoformsMembrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS.
P2860
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P2860
Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Phosphorylation of p47phox dir ...... ocyte NADPH oxidase activation
@ast
Phosphorylation of p47phox dir ...... ocyte NADPH oxidase activation
@en
Phosphorylation of p47phox dir ...... ocyte NADPH oxidase activation
@nl
type
label
Phosphorylation of p47phox dir ...... ocyte NADPH oxidase activation
@ast
Phosphorylation of p47phox dir ...... ocyte NADPH oxidase activation
@en
Phosphorylation of p47phox dir ...... ocyte NADPH oxidase activation
@nl
prefLabel
Phosphorylation of p47phox dir ...... ocyte NADPH oxidase activation
@ast
Phosphorylation of p47phox dir ...... ocyte NADPH oxidase activation
@en
Phosphorylation of p47phox dir ...... ocyte NADPH oxidase activation
@nl
P2093
P2860
P356
P1476
Phosphorylation of p47phox dir ...... ocyte NADPH oxidase activation
@en
P2093
Daisuke Kohda
Futoshi Kuribayashi
Hideki Sumimoto
Ryu Takeya
Tetsuro Ago
P2860
P304
P356
10.1073/PNAS.0735712100
P407
P577
2003-04-15T00:00:00Z