PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
about
PML nuclear bodiesThe proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growthTracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4EEmx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neuronsHuman homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHPMolecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2Control of biochemical reactions through supramolecular RING domain self-assembly.Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localizationExpression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cellsRole of ND10 nuclear bodies in the chromatin repression of HSV-1Infected cell protein 0 functional domains and their coordination in herpes simplex virus replicationThe cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodiesStructural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4ECrystal structure of a minimal eIF4E-Cup complex reveals a general mechanism of eIF4E regulation in translational repressionStructural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4EeIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognitioneIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTRPondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure.Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies.Translation of a small subset of Caenorhabditis elegans mRNAs is dependent on a specific eukaryotic translation initiation factor 4E isoform.Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA capA biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus.The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster.The flexible C-terminal arm of the Lassa arenavirus Z-protein mediates interactions with multiple binding partners.MYC in breast tumor progressionChromatin modification, leukaemia and implications for therapy.Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer.Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis.Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.Body language: the function of PML nuclear bodies in apoptosis regulation.Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development.Acute promyelocytic leukemia: PML/RARalpha and the leukemic stem cell.New sources of drugs for hematologic malignancieseIF4E is a central node of an RNA regulon that governs cellular proliferation.Further evidence that ribavirin interacts with eIF4E
P2860
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P2860
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA
@nl
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
@ast
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
@en
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
@en-gb
type
label
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA
@nl
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
@ast
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
@en
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
@en-gb
prefLabel
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA
@nl
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
@ast
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
@en
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
@en-gb
P2093
P2860
P3181
P356
P1433
P1476
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
@en
P2093
P2860
P304
P3181
P356
10.1093/EMBOJ/20.16.4547
P407
P577
2001-08-01T00:00:00Z