Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
about
Functional amyloid formation within mammalian tissue.Osteoactivin acts as downstream mediator of BMP-2 effects on osteoblast functionThe ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and compositionLocalization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 functionFunctions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomesEpitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartmentBLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organellesThe tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesisRetrotransposon insertion in SILV is responsible for merle patterning of the domestic dog.Clinical and cellular characterisation of Hermansky-Pudlak syndrome type 6Melanosomes--dark organelles enlighten endosomal membrane transportAmyloids: friend or foe?MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanomaA family of tetraspans organizes cargo for sorting into multivesicular bodiesPMEL Amyloid Fibril Formation: The Bright Steps of PigmentationBLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factorThe potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosisInactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentationSorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes.MHC class II presentation of gp100 epitopes in melanoma cells requires the function of conventional endosomes and is influenced by melanosomes.Comparative Bioinformatics Analyses and Profiling of Lysosome-Related Organelle Proteomes.Electron tomography of early melanosomes: implications for melanogenesis and the generation of fibrillar amyloid sheets.Equine multiple congenital ocular anomalies and silver coat colour result from the pleiotropic effects of mutant PMEL.Multiple splice variants within the bovine silver homologue (SILV) gene affecting coat color in cattle indicate a function additional to fibril formation in melanophores.Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesions.Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes.The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding.Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation.The refractive state of the eye in Icelandic horses with the Silver mutation.A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in Drosophila.Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanomaEndoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction.Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.A customized pigmentation SNP array identifies a novel SNP associated with melanoma predisposition in the SLC45A2 gene.Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenicMolecular origin of pH-dependent fibril formation of a functional amyloidInteraction of MC1R and PMEL alleles on solid coat colors in Highland cattle.Identification of genes related to white and black plumage formation by RNA-Seq from white and black feather bulbs in ducks.Silencing of GPNMB by siRNA inhibits the formation of melanosomes in melanocytes in a MITF-independent fashionEffects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17.
P2860
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P2860
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
description
2001 nî lūn-bûn
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2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年学术文章
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2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
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name
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@ast
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@en
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@en-gb
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@nl
type
label
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@ast
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@en
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@en-gb
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@nl
prefLabel
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@ast
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@en
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@en-gb
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@nl
P2093
P2860
P3181
P356
P1476
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
@en
P2093
P2860
P304
P3181
P356
10.1091/MBC.12.11.3451
P407
P577
2001-11-01T00:00:00Z