BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor
about
VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surfaceRab18 and a Rab18 GEF complex are required for normal ER structure.LRRK2 transport is regulated by its novel interacting partner Rab32The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFsRecycling Endosomes and Viral InfectionExosome Biogenesis, Regulation, and Function in Viral InfectionRab GTPase regulation of membrane identityDiscovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-IIFunction and regulation of the endosomal fusion and fission machineriesBLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery.Guanine nucleotide exchange factors (GEFs) have a critical but not exclusive role in organelle localization of Rab GTPases.Rab GAP cascade regulates dynamics of Ypt6 in the Golgi trafficThe Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes.The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3.SNAREs in the maturation and function of LROsMultiple Roles of VARP in Endosomal Trafficking: Rabs, Retromer Components and R-SNARE VAMP7 Meet on VARPInteraction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteinsRUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in MelanocytesSpatiotemporal dynamics of membrane remodeling and fusion proteins during endocytic transport.Rab13 Traffics on Vesicles Independent of Prenylation.BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriersEvidence for defective Rab GTPase-dependent cargo traffic in immune disorders.Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant lung surfactant homeostasis in Ruby rats.Dynamic association of the PI3P-interacting Mon1-Ccz1 GEF with vacuoles is controlled through its phosphorylation by the type 1 casein kinase Yck3.A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes.Tracking of the dynamic localization of the Rab-specific HOPS subunits reveal their distinct interaction with Ypt7 and vacuoles.Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5' splice site choiceMyosin vc interacts with Rab32 and Rab38 proteins and works in the biogenesis and secretion of melanosomesIn vitro functional correction of Hermansky-Pudlak Syndrome type-1 by lentiviral-mediated gene transfer.The role of the small GTPase Rab31 in cancer.Association of the Hermansky-Pudlak syndrome type 4 (HPS4) gene variants with cognitive function in patients with schizophrenia and healthy subjects.Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models.Hyperosmotic stress reduces melanin production by altering melanosome formation.Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.Chitinase 3-like-1 and its receptors in Hermansky-Pudlak syndrome-associated lung disease.Dominant spinal muscular atrophy is caused by mutations in BICD2, an important golgin protein.The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes.Rabex-5 protein regulates dendritic localization of small GTPase Rab17 and neurite morphogenesis in hippocampal neuronsA Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP.Review series: Rab GTPases and membrane identity: causal or inconsequential?
P2860
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P248
Q24298162-7478F199-6F68-46A3-B551-97899C967F77Q24298701-1EE16890-9900-45D1-A542-01C18A77134CQ24306357-11275B84-B4B9-45E1-A47E-025D47A82DB4Q24622048-3C71231D-E6F5-44A5-8FB8-A4A61F4B24F3Q26752566-760B9A2F-BD63-46DD-B9B5-5B3951BD4C45Q26782250-CC78957C-5EF4-4D47-88D4-AC971747E9F8Q26823807-676A2647-B0B5-4D79-89C9-6320B6A6DAB7Q27000977-2FCEA982-B4BE-49DC-9863-4E3F5892F298Q27015677-0A81347C-404C-4172-B797-A17F5F758395Q27310758-FC5FBAEC-440B-4A6E-A5F9-28D4A99D5E48Q27934171-7861235D-9752-47E2-B7CF-AE2219BE64E8Q27935395-6F27A84E-EF3C-41AA-A7E7-BB6962CC213CQ27939522-B5FEAF76-5431-4D73-A471-E01DD404E9DEQ27940067-02313E6E-FC99-4086-92D8-DE9E20F71DBFQ28071732-E1DE6985-7EC5-4D35-B097-5EDFCED326C6Q28071741-F643CD1A-30CB-48BB-AAB3-E114D56E9130Q28115441-00357FDF-1E9F-4768-AA98-DE96C3AA2407Q28117838-2A6C238E-298A-4013-9DE1-743635676808Q30652997-F819C7AF-F327-4692-90CF-D75ECA5AF666Q30756731-7761307E-B541-4BB0-9BD5-63E423A8E277Q30793347-56925D90-57E5-488B-8AD2-D9653B2C1230Q33408755-30F7F9FE-710C-4E76-90E9-0B5104FFA28BQ33595639-805AB3F3-E587-472D-9CA8-9D28FB3C4B3AQ33604383-9D53EF0E-CBA4-4206-9D4B-38224AD7BADEQ33933426-986C5F4F-E21B-42DF-B6E8-941DE1BB6990Q34142922-049A6B27-7C40-40DF-BB41-0322821059B4Q34465902-3D6086CD-6CFD-40E1-8214-464E76668157Q34580378-6ABE22B5-6EB7-4FA5-B432-8E50AFE5FF12Q34788332-0B3FDE53-C5C5-464D-902C-9FBACCF0CC98Q34885255-139C04DB-BAC4-437A-8767-6EA0CDA983C7Q35028101-7294EFCE-B1D7-4D77-8927-F2464ABA87A9Q35153219-BF8CE83D-B903-4F0F-8D3A-474DF75B94AEQ35235009-F30BD4F5-4618-46FC-B5CD-5785B013145FQ35840841-5AB12A0E-9C9C-4C18-8528-F9DD66CFAC5BQ36040475-14F80137-4F98-41DC-9468-3A505E80888DQ36249484-7B7EA78C-96C1-4029-BAAD-F7CC76248DADQ36673162-FC31B462-3273-4EF0-813B-CE9C1D5B4C79Q36742238-4EDA73AB-19BE-4579-ABB7-400BAAF28344Q36862416-DF6566A9-7B6A-44D1-83CF-4A0B2CFE3435Q37034278-8E7010A9-6570-4B14-A176-9907867CF595
P2860
BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor
description
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2012
@ast
im November 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2012/11/20)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd op 2012/11/20)
@nl
наукова стаття, опублікована в листопаді 2012
@uk
مقالة علمية (نشرت في 20-11-2012)
@ar
name
BLOC-3 mutated in Hermansky-Pu ...... ine nucleotide exchange factor
@ast
BLOC-3 mutated in Hermansky-Pu ...... ine nucleotide exchange factor
@en
BLOC-3 mutated in Hermansky-Pu ...... ine nucleotide exchange factor
@nl
type
label
BLOC-3 mutated in Hermansky-Pu ...... ine nucleotide exchange factor
@ast
BLOC-3 mutated in Hermansky-Pu ...... ine nucleotide exchange factor
@en
BLOC-3 mutated in Hermansky-Pu ...... ine nucleotide exchange factor
@nl
prefLabel
BLOC-3 mutated in Hermansky-Pu ...... ine nucleotide exchange factor
@ast
BLOC-3 mutated in Hermansky-Pu ...... ine nucleotide exchange factor
@en
BLOC-3 mutated in Hermansky-Pu ...... ine nucleotide exchange factor
@nl
P2093
P2860
P921
P3181
P1433
P1476
BLOC-3 mutated in Hermansky-Pu ...... ine nucleotide exchange factor
@en
P2093
Andrea Linford
Andreas Gerondopoulos
Lars Langemeyer
P2860
P304
P3181
P356
10.1016/J.CUB.2012.09.020
P407
P577
2012-10-18T00:00:00Z