A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
about
PH domain of ELMO functions in trans to regulate Rac activation via Dock180Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5Crucial structural role for the PH and C1 domains of the Vav1 exchange factorFAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)PCharacterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEFGalphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domainBves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activityThe DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activationRegulation of small GTPases by GEFs, GAPs, and GDIsNon-muscle myosin II regulates neuronal actin dynamics by interacting with guanine nucleotide exchange factorsCrystal structure of Rnd3/RhoE: functional implicationsCrystal structure of the rac activator, Asef, reveals its autoinhibitory mechanismStructural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav13D structure of a binary ROP-PRONE complex: the final intermediate for a complete set of molecular snapshots of the RopGEF reactionStructural insights into host GTPase isoform selection by a family of bacterial GEF mimicsThe Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor IntersectinStructural basis of Fic-mediated adenylylationStructural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complexPositive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cellsThe C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipidsStructural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factorLoss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targetingInteraction of alpha1-syntrophin with multiple isoforms of heterotrimeric G protein alpha subunitsMultifunctional roles for the PH domain of Dbs in regulating Rho GTPase activationRational design and characterization of a Rac GTPase-specific small molecule inhibitorAutoinhibition of GEF activity in Intersectin 1 is mediated by the short SH3-DH domain linker.Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteinsNovel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix.The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain.The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3.Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.Regulation of phosphoinositide levels by the phospholipid transfer protein Sec14p controls Cdc42p/p21-activated kinase-mediated cell cycle progression at cytokinesisStructure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF.The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migrationRhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity.Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1.
P2860
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P2860
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
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2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A crystallographic view of int ...... ed guanine nucleotide exchange
@nl
A crystallographic view of int ...... d guanine nucleotide exchange.
@ast
A crystallographic view of int ...... d guanine nucleotide exchange.
@en
A crystallographic view of int ...... d guanine nucleotide exchange.
@en-gb
type
label
A crystallographic view of int ...... ed guanine nucleotide exchange
@nl
A crystallographic view of int ...... d guanine nucleotide exchange.
@ast
A crystallographic view of int ...... d guanine nucleotide exchange.
@en
A crystallographic view of int ...... d guanine nucleotide exchange.
@en-gb
prefLabel
A crystallographic view of int ...... ed guanine nucleotide exchange
@nl
A crystallographic view of int ...... d guanine nucleotide exchange.
@ast
A crystallographic view of int ...... d guanine nucleotide exchange.
@en
A crystallographic view of int ...... d guanine nucleotide exchange.
@en-gb
P2093
P2860
P356
P1433
P1476
A crystallographic view of int ...... d guanine nucleotide exchange.
@en
P2093
David K Worthylake
Jason T Snyder
Kent L Rossman
Sharon L Campbell
P2860
P304
P356
10.1093/EMBOJ/21.6.1315
P407
P577
2002-03-01T00:00:00Z