Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins
about
Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activationStructural and Functional Characterization of the Kindlin-1 Pleckstrin Homology DomainMembrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin ActivationCrystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activationKindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit.Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.Structural and mechanical functions of integrins.Talins and kindlins: partners in integrin-mediated adhesion.Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3.Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activationSpatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tailsA role of kindlin-3 in integrin αMβ2 outside-in signaling and the Syk-Vav1-Rac1/Cdc42 signaling axisA conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesisNMR Characterization and Membrane Interactions of the Loop Region of Kindlin-3 F1 Subdomain.Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling.Kindlin-2 directly binds actin and regulates integrin outside-in signalingKindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis.Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism.The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties.Integrin signaling in vascular function.Neutrophil arrest by LFA-1 activationCell-matrix adhesion of podocytes in physiology and disease.Talin and kindlin: the one-two punch in integrin activation.The importance of podocyte adhesion for a healthy glomerulus.Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.Of Kindlins and CancerPodocyte-actin dynamics in health and disease.RhoA activation by CNFy restores cell-cell adhesion in kindlin-2-deficient keratinocytes.The kindlin 3 pleckstrin homology domain has an essential role in lymphocyte function-associated antigen 1 (LFA-1) integrin-mediated B cell adhesion and migrationA feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells.Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1).Interactions of Pleckstrin Homology Domains with Membranes: Adding Back the Bilayer via High-Throughput Molecular Dynamics.Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis.Efficient production and purification of recombinant murine kindlin-3 from insect cells for biophysical studies.Kindlin-2: a new player in renal fibrogenesis.The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation.Optogenetic interrogation of integrin αVβ3 function in endothelial cells.The binding interface of kindlin-2 and ILK involves Asp344/Asp352/Thr356 in kindlin-2 and Arg243/Arg334 in ILK.
P2860
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P2860
Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins
description
2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@ast
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@en
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@en-gb
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@nl
type
label
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@ast
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@en
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@en-gb
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@nl
prefLabel
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@ast
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@en
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@en-gb
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@nl
P2093
P2860
P3181
P356
P1476
Kindlin-2 regulates podocyte a ...... hosphoinositides and integrins
@en
P2093
Chuanyue Wu
Hannu Larjava
Koichi Fukuda
Moin A Saleem
Sanford J Shattil
Xiaohua Shi
P2860
P304
P3181
P356
10.1242/JCS.076976
P407
P577
2011-03-15T00:00:00Z